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Study aim
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Assessment and comparison of two standard protocols for management of asthma attack in patients admitted to Imam Khomeini and Golestan Hospitals emergency rooms in Ahwaz, Iran
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Design
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This study include 66 patients divided in two intervention and control groups; each group with 33 patient. It is a double blind study. Patients are coded in bases of table of random number, then are divided to two groups. Analyzer coding patients in basis of table of random numbers. Patients, research fellow and evaluator of events kept to be blind. This study is a phase 3 type clinical trial.
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Settings and conduct
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This is study will be done at Golestan and Imam Khomeini hospital of ahvaz.
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Participants/Inclusion and exclusion criteria
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Inclusion criteria: patients with clinical and para clinical approved asthma with clinical presentation of acute asthma attack and minimum age 18 years old and maximum 65 years old.
Exclusion criteria: COPD, CHF, pnumonia, lung disease, nursing mothers, pregnancy, fever, administration of salbutamol in the last 6 hours.
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Intervention groups
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Intervention group: the intervention group were recorded at 0, 20, 40, 60 spirometric values of FEV1 and PEFR were measured and recorded. For each patient to record the values of FEV1 and PEFR, 3 times a spirometry performed and is considered the highest number. Immediately after spirometry, nebulize salbutamol dose (2.5 mg), as well as magnesium sulfate 2.5 CC Of 20 g / 100CC done. The control group were recorded at 0, 20, 40, 60 spirometric values of FEV1 and PEFR were measured and recorded. For each patient to record the values of FEV1 and PEFR, 3 times a spirometry performed and is considered the highest number. Immediately after spirometry, nebulize salbutamol 2 / 5CC (2.5 mg), with 1.5 CC of saline in the control group will receive.
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Main outcome variables
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Clinical state; forced expiratory volume in first second; peak expiratory flow rate