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Study aim
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Determine the effects of Crataegus monogyna on Hypertension
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Design
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By using random numbers table, patients are divided in two groups ,case and control. All participants and researchers are blind in this study, coding of medicine and placebo are under the responsibility of a statistical adviser who is not blind.
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Settings and conduct
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Dry extract of Crataegus Monogyna with a concentration of 10% relative to 100 gr of the plant, has been standardized 250mg per capsule at the school of pharmacy of Shahid Behest university of Medical Sciences.The drug is given one capsule every 12 hours for 60 days to volunteer patient with hypertension(the patients refer to special clinic Zanjan university of Medical science)
Control group:Placebo in the control group contains starch corn which is provided in capsules and boxes of the same intervention group.the placebo is given one capsule every 12 hours for 60 days to volunteer patient with hypertension(the patients refer to special clinic Zanjan university of Medical science) All participations and researchers are blind in this study, coding of medicine and placebo are under the responsibility of a statistical adviser who isnot blind.
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Participants/Inclusion and exclusion criteria
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Informed study participation, age 35 to 60,Hypertension , continuing heart medications, prescribed by cardiologist.
Pregnancy,
Breast feeding,
Malignancy,
Sever hypertension,
Chronic Inflamatory diseas,
Renal failure,
Sever liver disease,
Acute infectious disease,
Secondary hypertension,
Age less than 35 and older than 60,
Taking digoxin,
Arryhthmia
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Intervention groups
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60 Patients have Hypertension at 35 to 60 years that conditions have in plan.30 person take placebo and 30 person take drug
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Main outcome variables
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1-Quality of sleep in the Pittsburgh Questionnaire
2- Systolic blood pressure
3- FBS,BUN,Cr,Hb, ALT,AST, TG