Introduction: Reduction of post operative nausea and vomiting accelerates discharge of patients and reduces healthcare costs, hospital re–admission and duration of hospitalization, and increases satisfaction of patients.
Methods:
This study was an interventional experiment performed on 180 patients undergoing GLS. Patients were selected from those who referred to afzalipoor hospital of Kerman for diagnostic GLS and were aged 18-35 with ASA I or II. This study was approved by the hospital ethics research committee [Code: EC/KNRC/88-169] and registered with the European Clinical Trials Database.
Exclusion criteria included: diabetes, addiction to drugs, history of nausea or vomiting and or using drugs with known anti-emetic properties (like metformin, clomifen, medroxy progestron, bromocriptin) 24 hours before the surgery, smoking, motion disease history, previous experience of PONV, surgical duration more than 45 minutes, usage of opioids after surgery in recovery period and weight more than 70kg. They were randomly allocated to three groups: alfentanil, sufentanil and fentanyl. After entrance of the patient to the OR, alfentanil 2cc (1000μg); fentanil 2cc (100μg); sufentanil 2cc (10μg) was administered to the three group of patients two minutes before I.V. induction of anesthesia to the patient. After surgery and extubation and entrance into recovery ward, incidence of nausea or vomiting was recorded from the entrance to the ward until 24 hours after surgery in the check list by a resident of anesthesiology who was blinded to the drug administered to the patient.