The effect of rehabilitation (strength and endurance exercises) on respiratory symptoms, lung function indexes and some inflammatory mediators in asthmatic patients.

Effect of strength and endurance exercises on respiratory symptoms, lung function and inflammatory mediators in asthmatic patients.

Intervention is limited to one group of eligible applicants (30 people) without randomization. This study does not have a control group.

Exercises will be done for 4 weeks (3 sessions/week). During each session after 10 minutes warming up,endurance training includes treadmills, bicycle and arm ergonomic for 15-20 minutes with Vo2 max = 60% for Elementary sessions, and gradually 60 minutes with Vo2 max = 70-80% for final sessions. Upon completion of endurance training, resistance training include weight lifting. In this exercise, one repetition maximum of the person is calculated first and 50-60% of the 1RM for a set with 15-10 repeats. Gradually, the sets number will reach 3. Static stretching of the entire body and finally cool down for 10 minutes.

Mild to moderate asthma ؛ Absence of acute illnesses that are in contradiction with exercise ؛ Age limit 20 to 60 years Severe asthma and acute diseases that is exacerbated by exercise ؛ Cardiovascular and chronic inflammatory diseases ؛ Acute infections ؛Malignant diseases and immune deficiency

After diagnosis of asthma of participants, patients in one group are subjected to intervention with strength and endurance exercises . At the end of the project (30 days), to determine the effect of the intervention, the rate Changes in lung function and asthma attacks , clinical signs, changes in asthma attacks, total and types of WBCs and inflammatory factors will be measured

Evaluation of disease symptoms and lung function tests Measurement of Eosinophil peroxidase, C-reactive protein, eNO Total and types of WBCs Measurement cytokines and inflammatory mediators ( TNFα, IL-6 , IL-8, IgE ، IgG) in serum

Data information will be published in article form.

Starting data access is six months after the article is printed.

Researchers in the field of medical science will be able to access the data.

Investigating requests will be reviewed by the research team.

Applicants must only coordinate with the responsible designer (Dr. Mohammad Hossein Boskabady) with access to the data only with the help of e-mail. Email address: boskabadymh@mums.ac.ir

After sending the request to the email of the responsible designer and the review of the type of request will eventually be notified within twenty days.