The efficacy and safety of atmospheric pressure plasma versus low-level laser therapy on chronic wounds (including dystrophic epidermolysis bullosa)

The efficacy and safety of atmospheric pressure plasma versus low-level laser therapy on chronic wounds (including dystrophic epidermolysis bullosa)

In this clinical trial, 6 patients with Dystrophic EB will be included and in each patient 5 wounds will be randomly selected for different kinds of treatment. In each patient, 2 wounds will be treated with plasma, 2 wounds with low level laser and one was dressed with standard wound care as the control.

The quality of wound healing will be assessed by evaluation of wound size and also a designed qualitative wound score (QWS), which evaluate the healing by scoring changes in four parameters as follows: (i) size (scores of 0, 1, and 2, indicating decreased size, no change or increased size, respectively); (ii) odour (0, no and 1, yes); (iii) exudate (scores of 0, 1 and 2 indicating none, mild and moderate to severe, respectively); and (iv) redness (scores of 0, 1 and 2 indicating none, pink and red, respectively). A dermatologist who is unaware of the assigned treatment for each lesion, recruit to assess the lesions before treatment, after each session of treatment (during treatment), 2, 6 and 12 weeks after treatment

- Inclusion criteria: Dystrophic EB patients with age over 10 years, old chronic wounds over 3 months, Full satisfaction for entrance to the study, without exclusion criteria - Exclusion criteria: Other comorbidities including collagen vascular diseases and vasculitis, coronary artery diseases, active infection, malignancy on the treatment area, Alcoholics and smokers

Dystrophic EB patients who have old chronic wounds over 3 months with no response to conventional treatments

Time of complete wound healing Dermatology Life Quality Index Qualitative wound score (QWS) Recurrence time

Data analysis will be done by a dermatologist who is unaware of the assigned treatment for each lesion