Inclusion criteria:
BMI 24.9 to 39.9
Women 18 years to premenopausal and men 18 to 60 years old
Consent to participate in the study
History of at least one monotherapy failure
Exclusion criteria:
Hypothyroidism, Cushing's syndrome, cancer, liver or kidney failure
Psychiatric disorders associated with eating like anorexia nervosa and hyperorexia
Using drugs effective on weight and metabolism in the previous month
Using drugs that interfere with Hypericum perforatum such as protease inhibitors, amiodarone, anticoagulants, cyclophosphamide, cyclosporine, monoamine oxidase inhibitors, phenytoin, tacrolimus, tamoxifen and trazodone drug
Drug abuser or alcoholism
Breast-feeding, pregnancy or planning a pregnancy during the next two months
Pacemaker and any metal device inside the body due to the use of Bioelectrical Impedance Analyzer
Disability to do recommended physical activity
Allergy to hypericum perforatum