The effect of folic acid mouthwash solution in prevention of head and neck radiotherapy –induced stomatitis

Determining the Effect of Folic Acid Mouthwash on Prevention of Stomatitis in Patients Under Head and Neck Radiotherapy. ________________________________________

Clinical trials with control and intervention group, with parallel and randomized groups.

This study was conducted in the Radiotherapy section of Imam Reza Hospital in Mashhad

Satisfaction to participate in the study, lack of immunosuppression and absence of leukocyte and leukocytosis, aged 18 to 60 years, lack of underlying disease (diabetes, kidney disease, liver disease), oral mucosa, and mucosal lesions, The daily intake of external radiation therapy with a dose of 200-180(cGary) for one hour, does not have a history of smoking in a recent month; the lack of simultaneous use of chemotherapy with radiation therapy during the study, lack of sedative, non-use of mouthwash and other medication for Oral ulceration during research, lack of artificial teeth,death, any complications that occur during the study and not able to participate in the study, fever above 38.3 ° C, lack of willingness to continue cooperation in the study, more Do not get 20% mouthwashes during the study

Combined folic acid solution containing folic acid = 100 mg, NaHCO3=38 mg, propyl parahydroxybenzoate = 25 mg, methyl parahydroxy benzoate = 50 mg, conc peppermint water= 2 ml, distilled water = Up to 100 ml volume) for 14 days at two times in the morning and at night for one minute and then routine mouthwash (magic) with a 15 minute interval and control group 2 times with a distance of more than 15 minutes in two turns In the morning and at night, routine mouthwash is used.

Severity of stomatitis، Severity of pain caused by stomatitis، Incidence of oral ulcers

Using a random number table with 0-9 assignment to two groups of intervention and control, then on the random numbers table, set the starting point to blinded and specify the sequences of the sequence of the group on the random numbers of the starting point with a blind eye And sequences of sequence numbers of the intervention and control group are determined.

Mouthwashes of folic acid and magic in similar containers and dividing the dishes into two groups (a, b) and delivering mouthwash to the patients by clinical care will not be known to the researcher in the relationship to the type of mouthwash.

Only the original outcome information

Starting the access period from 1399

Only for researchers working in academic and scientific institutions

Analysis of delivered data is allowed

Zahra gholami Gholamiz932@mums.ac.ir

In less than one month, information is provided to the applicant by email.