Comparison of the sedative effect with Dexmedetomidine-Midazolam and Fentanyl- Midazolam in patients who candidated for Phacoemulsification cataract surgery referred to Isfahan Feyz hospital from 2017-2018

Comparison and Determination of the sedative Effect of Fentanyl-dexmedetomidine Combination with Fentanyl-Midazolam during Phacoamulsification

Double blinded clinical trial randomized by Randome Allocation and simple random sampling parallel group design of 70 patients enrolled by inclusion and exclusion criteria in this study.

The use of two different drugs with specific doses in two groups and comparing their effect on the sedation level in cataract surgery by phacoamulsification in Feyz Hospital in Isfahan. The patient and Researcher unaware of which drugs are used for each patient.

Inclusion criteria:patients aged 18–85 years old ASA class 1 & 2 scheduled for phacoemulsification cataract surgery and exclusion criteria is refusing, mentally challenged patients , history of chronic use of sedatives, narcotics or alcohol , allergy to any of the study medications , patients with severe chronic obstructive pulmonary disease, Asthma,, history of cardiac disease (cardiac block and bradycardia) bradycardia (heart rate less than 50 beats per minute), systolic blood pressure less than 90 mm, Severe hepatic failure, uncontrolled diabetes, left ventricular failure (EF less than 30), and cerebrovascular disease,severe renal failures

The Intervention group is patient who candidated for phacoamulsification with Fentanyl-dexmedetomidine Combination and Control group is Patient who candidated for Phacoamulsification with Fentayl-Midazolam combination

Sedation level;

The division of patients into two groups is based on a simple random sampling and Random allocation

The study is double blinded.Patient and researcher are unaware of patient groups and type of medication.The medications are prepared by an anesthetist and encoded an then injected.Demographic information; Sedation level. The quality of pain relief and hemodynamic variables and complications are collected by a patient who is not aware of the type of drug and patient grouping.