Assessment of the effect of Vitamin D Supplementation on recurrence rate of nasal polyposis after endoscopic sinus surgery : A Triple Blinded Randomized Controlled Trial

Patients with sinonasal polyposis that are candidates for surgery with serum levels of 10-30 ng / ml vit D3 (Insufficiency) will be enrolled and randomly (blocking technique) assigned into two groups (the control and the case) and written informed consent will be obtained. Patients with Samter's triad randomly will be distributed in both groups. Before surgery, all patients will be treated for 10 days with oral prednisolone 10 mg and cefixime 400mg per day and fluticasone spray,2 puffs each nostril, once a day. VAS & SNOT-22 questionnaire and Meltzer endoscopic grading score will be recorded . Patients undergoing endoscopic sinus surgery by one surgeon .After surgery, both groups of patients will receive routine post operative management (debridement in the first week, fluticasone spray two puffs daily, irrigation, tab cefixime 400 mg daily for 10 days and montelukast for a month).The case group will be received oral vitamin D tablets 4000 IU ( single dose daily) for one month and the control group will be received placebo as the same manner. At the end of the first ,third and sixth month VAS and SNOT-22 and Meltzer endoscopic grading score will be recorded. For blinding; the pharmacist will provide the coded placebo and vit.D in same containers for the researcher, so the patients , the researcher and the statistical consultant wont be aware of the contents.

Vice chancellor for research ,Hamadan University of Medical Sciences