Protocol summary

Study aim
The effect of iron deficiency treatment on insulin resistance in women with type 2 diabetes and iron deficiency anemia
Design
Clinical trial, single group, before after study
Settings and conduct
The study will be conducted on women with type 2 diabetes and iron deficiency anemia, at the Shahid Beheshti Hospital, Qom. The outcomes associated with diabetes control (including Insulin resistance, Hemoglobin A1C and serum cholesterol), will be evaluated, before and after treatment of iron deficiency in 40 patients.
Participants/Inclusion and exclusion criteria
Inclusion criteria: Woman who has been diagnosed with type 2 diabetes more than one year, Age 30-50 years, Iron deficiency anemia with hemoglobin <12; Exclusion criteria: Insulin therapy, Polymenorrhea, Pregnancy, Breast-feeding
Intervention groups
Intervention group: Administration of Ferrous sulfate tablet of Rouzdarou pharmaceutical co, with dosage of 325 mg, taken orally, daily, for 6 months
Main outcome variables
Insulin resistance; Hemoglobin A1C

General information

Reason for update
Acronym
IRCT registration information
IRCT registration number: IRCT20170215032587N3
Registration date: 2018-07-22, 1397/04/31
Registration timing: registered_while_recruiting

Last update: 2018-07-22, 1397/04/31
Update count: 0
Registration date
2018-07-22, 1397/04/31
Registrant information
Name
Mohammad Aghaali
Name of organization / entity
Country
Iran (Islamic Republic of)
Phone
+98 912 751 5639
Email address
maghaali@muq.ac.ir
Recruitment status
Recruitment complete
Funding source
Expected recruitment start date
2018-05-22, 1397/03/01
Expected recruitment end date
2018-08-23, 1397/06/01
Actual recruitment start date
empty
Actual recruitment end date
empty
Trial completion date
empty
Scientific title
The effect of iron deficiency treatment on insulin resistance in women with type 2 diabetes and iron deficiency anemia
Public title
The effect of iron deficiency treatment on insulin resistance
Purpose
Treatment
Inclusion/Exclusion criteria
Inclusion criteria:
More than one year has passed since the diagnosis of type 2 diabetes Age 30-50 years Iron deficiency anemia with hemoglobin less than 12
Exclusion criteria:
Insulin therapy Polymenorrhea Chronic diarrhea History of gastrectomy CRP above 10 mg/L Pregnancy Breast-feeding
Age
From 30 years old to 50 years old
Gender
Female
Phase
3
Groups that have been masked
No information
Sample size
Target sample size: 40
Randomization (investigator's opinion)
N/A
Randomization description
Blinding (investigator's opinion)
Not blinded
Blinding description
Placebo
Not used
Assignment
Single
Other design features

Secondary Ids

empty

Ethics committees

1

Ethics committee
Name of ethics committee
Ethics Committee of Qom University of Medical Sciences
Street address
No. 83, Alley 4, Alley 1.1, Safashahr Street, Qom
City
Qom
Province
Ghoum
Postal code
3716987366
Approval date
2018-05-22, 1397/03/01
Ethics committee reference number
IR.MUQ.REC.1397.031

Health conditions studied

1

Description of health condition studied
Diabetes
ICD-10 code
E08
ICD-10 code description
Diabetes mellitus due to underlying condition

2

Description of health condition studied
Iron deficiency anemia
ICD-10 code
D50
ICD-10 code description
Iron deficiency anemia

Primary outcomes

1

Description
Insulin resistance
Timepoint
Six months after beginning treatment
Method of measurement
HOMA-IR formula

2

Description
Hemoglobin A1C
Timepoint
Six months after beginning treatment
Method of measurement
Blood test, High-performance liquid chromatography

Secondary outcomes

1

Description
The level of blood triglycerides
Timepoint
Six months after beginning treatment
Method of measurement
Blood test, Enzymatic photometric test

2

Description
The level of blood cholestrol
Timepoint
Six months after beginning treatment
Method of measurement
Blood test, Enzymatic test

Intervention groups

1

Description
Intervention group: Ferrous sulfate tablet, 325 mg, Rouzdarou pharmaceutical co, oral, daily, for 6 months
Category
Treatment - Drugs

Recruitment centers

1

Recruitment center
Name of recruitment center
Shahid Beheshti Hospital
Full name of responsible person
Mahmoud Parham
Street address
Shahid Beheshti Hospital, Shahid Beheshti Blvd, Qom
City
Qom
Province
Ghoum
Postal code
3719964797
Phone
+98 25 3612 2053
Email
Yasi.f_90@yahoo.com

Sponsors / Funding sources

1

Sponsor
Name of organization / entity
Ghoum University of Medical Sciences
Full name of responsible person
Hossein Saghafi
Street address
No. 83, Alley 4, Alley 1.1, Safashahr Street, Qom
City
Qom
Province
Ghoum
Postal code
3716987366
Phone
+98 25 3285 2720
Email
hsaghafi@muq.ac.ir
Grant name
Grant code / Reference number
Is the source of funding the same sponsor organization/entity?
Yes
Title of funding source
Ghoum University of Medical Sciences
Proportion provided by this source
100
Public or private sector
Public
Domestic or foreign origin
Domestic
Category of foreign source of funding
empty
Country of origin
Type of organization providing the funding
Academic

Person responsible for general inquiries

Contact
Name of organization / entity
Ghoum University of Medical Sciences
Full name of responsible person
Mojtaba Tavasoli
Position
Qom
Latest degree
Specialist
Other areas of specialty/work
Internal Medicine
Street address
Shahid Beheshti Hospital, Shahid Beheshti Blvd, Qom
City
Qom
Province
Ghoum
Postal code
3719964797
Phone
+98 25 3612 2053
Email
Yasi.f_90@yahoo.com

Person responsible for scientific inquiries

Contact
Name of organization / entity
Ghoum University of Medical Sciences
Full name of responsible person
Mahmoud Parham
Position
Associate professor
Latest degree
Subspecialist
Other areas of specialty/work
Internal Medicine
Street address
Shahid Beheshti Hospital, Shahid Beheshti Blvd, Qom
City
Qom
Province
Ghoum
Postal code
3719964797
Phone
+98 25 3612 2053
Email
Mahmoud51@yahoo.com

Person responsible for updating data

Contact
Name of organization / entity
Ghoum University of Medical Sciences
Full name of responsible person
Mojtaba Tavasoli
Position
Qom
Latest degree
Specialist
Other areas of specialty/work
Internal Medicine
Street address
Shahid Beheshti Hospital, Shahid Beheshti Blvd, Qom
City
Qom
Province
Ghoum
Postal code
3719964797
Phone
+98 25 3612 2053
Email
Yasi.f_90@yahoo.com

Sharing plan

Deidentified Individual Participant Data Set (IPD)
No - There is not a plan to make this available
Justification/reason for indecision/not sharing IPD
The data are specific to this study
Study Protocol
No - There is not a plan to make this available
Statistical Analysis Plan
No - There is not a plan to make this available
Informed Consent Form
No - There is not a plan to make this available
Clinical Study Report
No - There is not a plan to make this available
Analytic Code
No - There is not a plan to make this available
Data Dictionary
No - There is not a plan to make this available
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