Protocol summary

Study aim
investigate the effect of teaching of dialectical behavioral therapy skills (DBT-ST) on cognitive functions in patients undergoing methadone maintenance therapy.
Design
The present study is a semi experimental design with pretest-posttest with control group. First, the researcher will refer to the addiction treatment clinics by conducting clinical interviews with the people who will have the criteria for entering the study, and then the participants will be randomly assigned using a random number table. The two groups will be treated and controlled.
Settings and conduct
40 patients will be selected in the study with a diagnosis of dependence on eligible opioids and referred to Omid Clinic, Kashan, Teachers' Square, Iran. Double-blind clinical trial parallel.
Participants/Inclusion and exclusion criteria
Inclusion criteria Age range from 18 to 45 years Detection of opioid dependence (opium, sap and heroin) Treated at least one month of MMT consent to participate in study Level of at least third degree education (cycle) Exit criteria: Positive morphine test during initial assessment and post-test The presence of a phase of mania or current depression The presence of psychoactive or micropsychotic courses in patients There is a history of head injury that has led to anesthesia Four absentee sessions for each patient during treatment
Intervention groups
The first group will receive training for dialectical behavioral therapy (DBT-ST) for 12 weeks. The second group will be treated with methadone for 12 weeks
Main outcome variables
Risk Decision Making using Gambling Assignment (IGT), Attention with Continuous Performance Task (CPT), Cognitive Flexibility Using Wisconsin Card Classification (WCST), Planning using London Tower Execution (TOL), Problem Solving Using the Wisconsin Card Classification (WCST), psychological symptoms using the Dass-42 questionnaire

General information

Reason for update
Acronym
IRCT registration information
IRCT registration number: IRCT20180721040541N1
Registration date: 2018-09-26, 1397/07/04
Registration timing: prospective

Last update: 2018-09-26, 1397/07/04
Update count: 0
Registration date
2018-09-26, 1397/07/04
Registrant information
Name
kiamars khezrian
Name of organization / entity
Country
Iran (Islamic Republic of)
Phone
+98 31 5554 0021
Email address
khezrian-k@kaums.ac.ir
Recruitment status
Recruitment complete
Funding source
Expected recruitment start date
2018-10-02, 1397/07/10
Expected recruitment end date
2018-12-11, 1397/09/20
Actual recruitment start date
empty
Actual recruitment end date
empty
Trial completion date
empty
Scientific title
study of the Effect of Dialectical Behavior Therapy – Skills Training (DBT-ST) on Cognitive Function in Methadone Maintenance Treatment Patients.
Public title
The Effect of Dialectical Behavior Therapy – Skills Training (DBT-ST) on Cognitive Function
Purpose
Treatment
Inclusion/Exclusion criteria
Inclusion criteria:
Age range from 18 to 45 years Detection of opioid dependence (opium, sap and heroin) Treatment for at least one month with methadone Participant consent Level of at least third degree education (cycle)
Exclusion criteria:
Positive morphine test during initial assessment and post-test The presence of a phase of mania or current depression The presence of psychoactive or micropsychotic courses in patients There is a history of head injury that has led to anesthesia Four absentee sessions for each patient during treatment
Age
From 18 years old to 45 years old
Gender
Male
Phase
N/A
Groups that have been masked
  • Care provider
  • Outcome assessor
  • Data analyser
Sample size
Target sample size: 40
Randomization (investigator's opinion)
Randomized
Randomization description
Randomization with random numbers, simple randomization.
Blinding (investigator's opinion)
Double blinded
Blinding description
Individual and group data are not coded as code and analytical and evaluation results are not known from the titles of individuals and groups.
Placebo
Not used
Assignment
Parallel
Other design features

Secondary Ids

empty

Ethics committees

1

Ethics committee
Name of ethics committee
Ethics Committee of Kashan University of Medical Sciences
Street address
Ghotbe Ravandi Boulevard, Kashan
City
kashan
Province
Isfehan
Postal code
8715981151
Approval date
2018-06-20, 1397/03/30
Ethics committee reference number
IR.KAUMS.MEDNT.REC.1397.016

Health conditions studied

1

Description of health condition studied
Mental and behavioral disorders due to the use of opioids
ICD-10 code
F11
ICD-10 code description
Mental and behavioral disorders due to the use of opioids

Primary outcomes

1

Description
Risky Decision Making
Timepoint
Before the intervention , after intervention
Method of measurement
Iowa gambling task

Secondary outcomes

1

Description
Attention
Timepoint
Before the intervention , after intervention
Method of measurement
Continuous performance task

2

Description
Cognitive Flexibility
Timepoint
Before the intervention , after intervention
Method of measurement
Wisconsin card sorting test

3

Description
Planning
Timepoint
Before the intervention , after intervention
Method of measurement
London Tower Test

4

Description
Problem - Solving
Timepoint
Before the intervention , after intervention
Method of measurement
Wisconsin card sorting test

5

Description
Psychological Signs
Timepoint
Before the intervention , after intervention
Method of measurement
DASS-42

Intervention groups

1

Description
Intervention group: DBT-ST (Methadone maintenance treatment)
Category
Behavior

2

Description
Control group: MMT
Category
Treatment - Drugs

Recruitment centers

1

Recruitment center
Name of recruitment center
Omid addiction treatment clinic
Full name of responsible person
Majid farhad
Street address
Teachers' Square, Motahari Boulevard
City
Kashan
Province
Isfehan
Postal code
8715981151
Phone
+98 31 5554 8627
Email
kiomarskhezrian@gmail.com

Sponsors / Funding sources

1

Sponsor
Name of organization / entity
Kashan University of Medical Sciences
Full name of responsible person
Gholamali Hamidi
Street address
Kashan, Rowdani Bolt
City
kashan
Province
Isfehan
Postal code
8715981151
Phone
+98 31 5554 2999
Email
hamidi_gh@kaums.ac.ir
Grant name
Grant code / Reference number
Is the source of funding the same sponsor organization/entity?
Yes
Title of funding source
Kashan University of Medical Sciences
Proportion provided by this source
100
Public or private sector
Public
Domestic or foreign origin
Domestic
Category of foreign source of funding
empty
Country of origin
Type of organization providing the funding
Academic

Person responsible for general inquiries

Contact
Name of organization / entity
Kashan University of Medical Sciences
Full name of responsible person
kiamars khezrian
Position
Master student
Latest degree
Bachelor
Other areas of specialty/work
Psychology
Street address
Ghotbe Ravandi Boulevard, Kashan
City
Kashan
Province
Isfehan
Postal code
8715981151
Phone
+98 31 5554 2999
Email
kiomarskhezrian@gmail.com

Person responsible for scientific inquiries

Contact
Name of organization / entity
Kashan University of Medical Sciences
Full name of responsible person
Zahra zanjani
Position
Assistant Professor
Latest degree
Ph.D.
Other areas of specialty/work
Psychology
Street address
ghotbe ravandi Boulevard , Kashan
City
Kashan
Province
Isfehan
Postal code
8715981151
Phone
+98 31 5554 0021
Email
z-zanjani@gmail.com

Person responsible for updating data

Contact
Name of organization / entity
Kashan University of Medical Sciences
Full name of responsible person
Zahra Zanjani
Position
Assistant Professor
Latest degree
Ph.D.
Other areas of specialty/work
Psychology
Street address
Kashan, Rowdani Bolt
City
Kashan
Province
Isfehan
Postal code
8715981151
Phone
+98 31 5554 0021
Email
Z_zanjani@gmail.com

Sharing plan

Deidentified Individual Participant Data Set (IPD)
Undecided - It is not yet known if there will be a plan to make this available
Study Protocol
Undecided - It is not yet known if there will be a plan to make this available
Statistical Analysis Plan
Undecided - It is not yet known if there will be a plan to make this available
Informed Consent Form
Undecided - It is not yet known if there will be a plan to make this available
Clinical Study Report
Undecided - It is not yet known if there will be a plan to make this available
Analytic Code
Undecided - It is not yet known if there will be a plan to make this available
Data Dictionary
Undecided - It is not yet known if there will be a plan to make this available
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