evaluation of effect of Vitamin D supplementation on hypercalciuria in vitamin D deficient recurrent stone former patients

evaluation of effect of vitamin D supplement on urinary calcium and stone forming rate of patients with urilithiasis and vitamin D deficiency

patients aged 20 to 65 years who suffered vitamin D deficiency (serum vitamin D level < 30 ng/ml) and also history of nephrolithiasis with at least two episodes of stone recurrence or increase in stone size within the last five years who have not exclusion criteria will be included. serum levels of calcium, creatinine, uric acid, 25OHD, and parathormone and 24-hour urine concentration of creatinine, citrate, oxalate, sodium, uric acid, and calcium at the time of enrollment and three months after starting the vitamin D consumption will be measured. then this parameters with information like age,sex,BMI and hypertension if exists will be analyzed with SPSS software.

out patients who referred to nephrology department of Shariati hospital or private clinic of the researcher

urinary stone former patients who have vitamin D deficiency and sign the constant form and have not below criteria: pregnant patients, hypercalcemia (baseline calcium level of ≥10.4 mg/dl), medications that affect calcium and bone metabolism (such as calcium) or calcium excretion (such as steroidal or hormonal drugs), previous history of primary hyperparathyroidism or other systemic diseases (cancer, alcoholic liver disease and osteoporosis) patients who had invasive diagnostic or therapeutic interventions on renal stones within the last month prior to enrollment known case of uric acid ,cysteine or steruvite urinary stone

All 30 patients with inclusion criteria who have not exclusion criteria receive vitamin D pearl and after and before intervention lab test will be compare

changes rate of 24 hour urine calcium and amount of new stone formation