This study was a randomized and single blind clinical trial to determine the effects of creatine and carnitine supplementation on anaerobic performance, energy metabolism (lactic acid, TG), interleukin-6, malondialdehyde, glutathione peroxidase, BUN, blood creatinine and creatinine 24 hour urine in athletes martial. 48 male athletes who have just started this sport at the age between 18 to 30 years, no history of liver disease, cardio - vascular problems, muscular - skeletal, lung, and not receiving protein supplement during the past few months to be reviewed are. A candidate's consent to participate in this study was fulfiiled. During the supplementation period (4 weeks) someone with a cold or diarrhea, are excluded. Volunteers randomly divided into 4 groups of 12 people are following: athletes with creatine supplementation ( 0.3 g / kg / d for 7 days and 0.03 g / kg / d , followed by 21 days); athletes with carnitine supplementation ( 2 g / d for every 28 days); athletes and carnitine supplementation with creatine supplementation (0.3 g / kg / d for 7 days and 0.03 g / kg / d for 21 days followed by addition 2 g / d for each person for 28 days ) and athletes receiving placebo. Beginning and end of the performance indicators anaerobic, lactate, TG, IL-6, malondialdehyde and glutathione peroxidase, BUN, creatinine, and creatinine 24 hour urine were measured.