Protocol summary

Study aim
Tthe aim of the study was to compare the efficacy and potential complications of home-applied and in-office bleaching systems activated by different light sources in patients with discolored teeth after orthodontic treatment.
Design
The sample consisted of sixty volunteers with the chief complaint of tooth discoloration following orthodontic treatment. All the participants had discoloration in anterior maxillary teeth and their central incisors showed shade C2 or darker on the value-oriented shade guide. This study is a randomized single-blind clinical trial study.
Settings and conduct
the study was enrolled in the Department of Restorative Dentistry of Mashhad Dental School, Mashhad University of Medical Sciences, Mashhad, Iran.the study is single blind. (evaluator and statistician).
Participants/Inclusion and exclusion criteria
Volunteers referring to the Mashhad Dental School who have been past their orthodontic treatment for three months and have a clear color change in six anterior teeth The exclusion criteria were patients who were pregnant or lactating; had moderate or severe discoloration resulting from pulpless teeth, tetracycline stains or fluorosis, as well as patients having smoking habits or those taking analgesic and anti-inflammatory drugs. Patients showing restored anterior teeth, non-carious cervical lesions, dental caries, periodontal disease or gingival recession, and subjects with previous tooth whitening procedures were also excluded from the sample
Intervention groups
group 1 received home bleaching group 2 received in-office bleaching with the use of diode laser group 3 received in-office bleaching with the use of plasma arc group 4 received in-office bleaching without light source
Main outcome variables
Study group (by whitening method) Color change rate Severity of pain and tooth sensitivity Complications after treatment

General information

Reason for update
Acronym
IRCT registration information
IRCT registration number: IRCT20180912041012N1
Registration date: 2018-10-25, 1397/08/03
Registration timing: registered_while_recruiting

Last update: 2018-10-25, 1397/08/03
Update count: 0
Registration date
2018-10-25, 1397/08/03
Registrant information
Name
Salehe Sekandari
Name of organization / entity
Country
Iran (Islamic Republic of)
Phone
+98 51 3882 9501
Email address
sekandaris961@mums.ac.ir
Recruitment status
Recruitment complete
Funding source
Expected recruitment start date
2018-10-23, 1397/08/01
Expected recruitment end date
2018-11-22, 1397/09/01
Actual recruitment start date
empty
Actual recruitment end date
empty
Trial completion date
empty
Scientific title
Evaluation of efficacy and complications of several bleaching techniques on tooth discoloration following orthodontic treatment
Public title
Efficacy of several bleaching techniques following orthodontic treatment
Purpose
Treatment
Inclusion/Exclusion criteria
Inclusion criteria:
Patients who have been past 3 months of their orthodontic treatment Significant tooth discoloration in the six anterior teeth
Exclusion criteria:
Severe internal discolorations (tetracycline, fluorosis) Periodontal disease Tooth decays or restorations Tooth sensitivity Gastrointestinal disease
Age
From 14 years old to 30 years old
Gender
Both
Phase
N/A
Groups that have been masked
  • Outcome assessor
  • Data analyser
Sample size
Target sample size: 60
Randomization (investigator's opinion)
Randomized
Randomization description
The group allocation was achieved by computer-generated tables-using random block size of 4. The details of the allocated groups were written on cards and were kept in sequentially numbered, opaque, and sealed envelopes. These cards were prepared by an independent operator who was not involved in the research protocol.
Blinding (investigator's opinion)
Single blinded
Blinding description
The person evaluating the results of colorimetry and dental sensitivity ,complications and satisfaction of patients questionnaire and an the statistician was blind.
Placebo
Not used
Assignment
Parallel
Other design features

Secondary Ids

empty

Ethics committees

1

Ethics committee
Name of ethics committee
Ethics committee of Mashhad University of Medical Sciences
Street address
At the beginning of the Vakil Abad Blvd., Mashhad
City
Mashhad
Province
Razavi Khorasan
Postal code
9138735499
Approval date
2016-02-03, 1394/11/14
Ethics committee reference number
IR.mums.sd.REC.1394.84

Health conditions studied

1

Description of health condition studied
TOOTH DISCOLORATION
ICD-10 code
ICD-10 code description

Primary outcomes

1

Description
Color change rate
Timepoint
Before treatment (T1), 1 hour after the end of the bleaching procedure(T2), and one week after the end of the bleaching procedure(T3).
Method of measurement
Spectrometer device

2

Description
Tooth sensitivity rate
Timepoint
Before treatment (T1), 1 hour after the end of the bleaching procedure(T2), and one week after the end of the bleaching procedure(T3).
Method of measurement
Visual Analogue Scale

3

Description
Incidence or absence of complications and patient satisfaction
Timepoint
One week after the end of the bleaching procedure
Method of measurement
Inventory

Secondary outcomes

empty

Intervention groups

1

Description
Intervention group: Home bleaching
Category
Treatment - Other

2

Description
Intervention group: Laser-assistant in-office bleaching
Category
Treatment - Other

3

Description
Intervention group: Plasma arc-assistant in-office bleaching
Category
Treatment - Other

4

Description
Intervention group: Not light activated in-office bleaching
Category
Treatment - Other

Recruitment centers

1

Recruitment center
Name of recruitment center
Mashhad Dental School
Full name of responsible person
Salehe Sekandari
Street address
At the beginning of the Vakil Abad Blvd., Mashhad
City
Mashhad
Province
Razavi Khorasan
Postal code
9177948959
Phone
+98 51 3882 9501
Fax
+98 51 3882 9500
Email
sekandaris961@mums.ac.ir
Web page address
http://dentistry.mums.ac.ir/

Sponsors / Funding sources

1

Sponsor
Name of organization / entity
Mashhad University of Medical Sciences
Full name of responsible person
Farzane Ahrari
Street address
At the beginning of the Vakil Abad Blvd., Mashhad
City
Mashhad
Province
Razavi Khorasan
Postal code
9177948959
Phone
+98 51 3882 9501
Fax
Email
sekandaris961@mums.ac.ir
Web page address
http://dentistry.mums.ac.ir/
Grant name
Grant code / Reference number
Is the source of funding the same sponsor organization/entity?
Yes
Title of funding source
Mashhad University of Medical Sciences
Proportion provided by this source
100
Public or private sector
Public
Domestic or foreign origin
Domestic
Category of foreign source of funding
empty
Country of origin
Type of organization providing the funding
Academic

Person responsible for general inquiries

Contact
Name of organization / entity
Mashhad University of Medical Sciences
Full name of responsible person
Salehe Sekandari
Position
Resident
Latest degree
Medical doctor
Other areas of specialty/work
Dentistry
Street address
At the beginning of the Vakil Abad Blvd., Mashhad
City
Mashhad
Province
Razavi Khorasan
Postal code
9177948959
Phone
+98 51 3882 9501
Email
sekandaris961@mums.ac.ir
Web page address
http://dentistry.mums.ac.ir/

Person responsible for scientific inquiries

Contact
Name of organization / entity
Mashhad University of Medical Sciences
Full name of responsible person
Salehe Sekandari
Position
Resident
Latest degree
Medical doctor
Other areas of specialty/work
Dentistry
Street address
At the beginning of the Vakil Abad Blvd., Mashhad
City
Mashhad
Province
Razavi Khorasan
Postal code
9177948959
Phone
+98 51 3882 9501
Email
sekandaris961@mums.ac.ir

Person responsible for updating data

Contact
Name of organization / entity
Mashhad University of Medical Sciences
Full name of responsible person
Salehe Sekandari
Position
Resident
Latest degree
Medical doctor
Other areas of specialty/work
Dentistry
Street address
At the beginning of the Vakil Abad Blvd., Mashhad
City
Mashhad
Province
Razavi Khorasan
Postal code
9177948959
Phone
+98 51 3882 9501
Email
sekandaris961@mums.ac.ir

Sharing plan

Deidentified Individual Participant Data Set (IPD)
Yes - There is a plan to make this available
Study Protocol
Undecided - It is not yet known if there will be a plan to make this available
Statistical Analysis Plan
Undecided - It is not yet known if there will be a plan to make this available
Informed Consent Form
Undecided - It is not yet known if there will be a plan to make this available
Clinical Study Report
Undecided - It is not yet known if there will be a plan to make this available
Analytic Code
Undecided - It is not yet known if there will be a plan to make this available
Data Dictionary
Undecided - It is not yet known if there will be a plan to make this available
Title and more details about the data/document
Tooth color evaluation date and complication questionnaire data
When the data will become available and for how long
6 month after Publishing the results
To whom data/document is available
Researchers working in academia
Under which criteria data/document could be used
For meta-analysis studies
From where data/document is obtainable
By Email sekandaris961@mums.ac.ir
What processes are involved for a request to access data/document
About a month due to a review of the request by the authors
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