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Study aim
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To investigate and compare the efficacy of administration of gluten free diet on clinical symptoms and signs, quality of life, and inflammatory factors in patients with irritable bowel syndrome under low FODMAP diet
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Design
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Randomized Clinical Trial
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Settings and conduct
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In this study, patients with irritable bowel syndrome referring to Taleghani Hospital, if they wish to participate in the study informed consent of them will be taken. All patients undergo low FODMAP+strict gluten free diet after delivery of blood and stool samples for 6 weeks. In the second 6 weeks, they will be randomly assigned to one of the three intervention and control groups, and the blood and stool samples and scores will be evaluated for the evaluation of IBS symptoms.
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Participants/Inclusion and exclusion criteria
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1)18-65 years
2) Patients with irritable bowel syndrome, according to gastroenterologist diagnosed according to the ROME- IV criteria
3) lack of any organic intestinal disease(diagnosed by last 5 years ago colonoscopy) and intestinal infections(diagnosed by stool culture).
4) No medical history of chronic gastrointestinal and colorectal disease Absence of any major bowel surgery
5) Absence of regular use of laxatives or antidiarrheal drugs
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Intervention groups
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1) Group I: will receive food products with 8g/day gluten for first 2 weeks, 16g/day gluten for second 2 weeks, following 32g/day gluten for third 2 weeks.
2) Group II: will continue low FODMAP+ strict (Gluten free) diet for 6 weeks.
3) Control group: will receive free diet for 6 weeks.
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Main outcome variables
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Age, Sex, Smoking, Weight, Height, Body Mass Index(BMI), Total energy intake, Total carbohydrate intake, Total fat intake, Total protein intake, Total fiber intake, Total SFA intake, Total MUFA intake, Total PUFA intake, serum level of IL-6 and INF-ɣ