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Study aim
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Evaluation of the effect of oral hyoscine on improvement of Bishop score in first term pregnancy
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Design
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One hundred primiparous women referred to the Obstetrics and Gynecology Clinic of Mahdieh Hospital of Tehran were divided into two groups of oral administration of hyoscine and control (expected treatment) using randomized number table, according to the order of entry.
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Settings and conduct
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After obtaining a clinical history and vaginal examination of the participants, Bishop score is also calculated and recorded. Then the patients are randomly divided into two groups: hyoscine and control. At the time of admission for delivery, Bishop score is again calculated and recorded. During the course of the study, all patients were followed up by telephone, finally Bishop score, delivery time, rate late term or prolonged pregnancy, type of delivery, and neonatal characteristics were compared between the two groups.
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Participants/Inclusion and exclusion criteria
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Age over 18 years, primiparous, gestational age 39 weeks, 0 days to 40 weeks and 0 days, spontaneous pregnancy, single pregnancy, cephalic presentation, absence of placenta previa or placental detachment (decollement), Bishop score equal to or less than 5, absence Fetal distress, absence of IUGR or macrosomal infant (embryo weighing more than 4000 gr), no underlying disease, such as diabetes or pre-pregnancy or pregnancy hypertension, no history of cervical trauma, cervical surgery or uterine surgeries, absence of hyoscine susceptibility, no use of narcotics or analgesics, no glaucoma, no cardiovascular disease, or tachycardia with more than 100 beats per minute
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Intervention groups
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Group 1: taking oral hyoscine 10 mg twice daily for one week and then once a day in the second week at entering to the study (39-40 weeks)
Group 2 (control): Expected treatment
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Main outcome variables
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Cervix status