Efficacy of midazolam on blood pressure control in patients attending to emergency ward with hypertension crisis

Determine the effectiveness of midazolam in blood pressure control in patients presenting to the emergency department with a diagnosis of hypertensive crisis

If the code in envelope A is patient with captopril and distilled water, if the code is B, it is a medication called Midazolam and a placebo of vitamin B, and if the code C is given, then Midazolam and Captopril will be prescribed.

This is a triple-blind clinical trial that will be performed on hypertensive patients referred to Emergency Hospital of Imam Hossein Shahroud Hospital.

Inclusion criteria: systolic or diastolic blood pressure above 180 on 110 mm Hg, the age group of 80-18 years, have the power to understand and sign an informed consent. Exclusion criteria: Acute left heart failure, Chronic renal failure, cardiovascular disease, History of stroke, History of myocardial infarction, Benzodiazepines consumed in the last week, Use muscle relaxants such as baclofen or anti-anxiety drugs, Other groups such as Zolpidem or Buspirone, Captopril susceptibility, Sensitivity to midazolam, Pregnant and lactating women, The occurrence of a critical condition, according to the doctor's opinion, requires the administration of a low blood pressure medication other than midazolam and captopril. Patients with a difference between the two arms are more than 15 mm Hg.

This study is randomly divided into three groups of 43 people. The two main drug captopril sublingual orally (25 mg) and midazolam intravenous injection (1 mg) will take place. Two placebos will be used in this program, which includes oral pills of vitamin B instead of captopril and distilled water instead of midazolam. After obtaining informed consent, patients will be randomly divided into three groups according to the order of the envelope.

hypertension

Patients were randomly assigned to three groups of 43 individuals using Random allocation software and from the first patient who has met criteria for the allocation of treatments based on randomization, everyone is treated with their medication.

Participant: The use of placebo in addition to the current drug was administered in a group of captopril tablets and placebo, distilled water, and in the second group, the drug was injected with midazolam and vitamin B tablets, and in the third group of captopril tablets and midazolam injectable drug. Outcome evaluator: The blood pressure meter will be measured before and after the intervention by the nurse present in the shift, who is unaware of how the medications are allocated to the patient. DATA ANALYSIS: No information is available on how to allocate drugs to the groups.

All collected data will be shared after being unidentified and analyzed

By the end of 2019

For all scholars

For use in studies

Supervisor

By email and correspondence and justification for use