Comparison of the Effectiveness of Pressure and Volume controlled Ventilation on the Intracuff Pressure and Air Leakage around the Cuff of the Endotracheal Tube in anesthetized and Mechanically ventilated Patients

Determination and Comparison of the Effect of Pressure controlled Ventilation Mode and Volume controlled Ventilation Mode on Cuff Pressure and Air Leakage around the Cuff of the Endotracheal Tube in Patients under general Anesthesia and Mechanical Ventilation.

Clinical Trial with Control Group, with parallel Groups, Triple blind, randomized

In this Study, 50 Patients with open-ended Surgery and Inguinal Hernia in the Operating Room of Imam Hossein Hospital of Shahroud were randomly divided into Two Groups: P and V. The P Group is placed on the PCV Mode and the V Group is placed on a VCV Mode. Initially, the Cuff Pressure will be adjusted to 25 Cmh2o for Both Groups. After the Intervention, the Cuff Pressure and the Amount of CO2 in the Supra-Glottic Space in Both Groups were measured and recorded after 10, 20 and 30 Minutes. Patients, the Person who measures the Variables and the Data Analyzer, respectively, with Anesthesia, Covering the Ventilator Mode and Coding the Two Groups of P and V into A and B, are blinded.

Patients aged 18-40 Years old and Ready for open-ended Surgery and Inguinal Hernia in supine Position, ASA1&2 and BMI=18-24.

In Group P (Intervention), Patients are placed on the PCV Mode (the Intervention in this Study) and the Airway Pressure is adjusted to reach a Volume of 7ml / kg and in Group V (Control), Patients will be placed on the VCV Mode (Routine Ventilation Mode) and a Tidal Volume of 7 ml / kg will be adjusted. Cuff Pressure and the Amount of CO2 (as an Indicator of Air Leakage) in the Supra glottic Space (with Capnograph) is measured and recorded in both Groups after 10, 20 and 30 Minutes, and compared together will be.

Changes in Cuff Pressure of the Endotracheal Tube; Changes in the Amount of Air Leakage around the Cuff

Patients are selected based on Entry and Exit Criteria. After Obtaining informed Consent from the Patients, they are assigned to the Two Groups of p and v Using the Random quadratic Block Method. In this Method, a Table of 50 Letters of the Letters p and v is prepared and then, to observe the Random Allocation Hiding, each of These Letters is enclosed in a sealed Envelope, Respectively. After Closing the Door, each Envelope on it is numbered, in the Order of the original Table. After Selecting a qualified Patient, the Envelope for that Patient is opened and, based on the Letters inside, the Patient is assigned to one of the Two Groups.

This Research is a Triple blind Study. The Patients Undergoing general Anesthesia prior to the Intervention and are blinded. The trained Person who measures the Cuff Pressure and Air Leakage is blinded by Covering the Ventilator and uncertain Ventilator Mode. The Data Analyzer is blinded by the Coding of the Two Study Groups (P and v) to the Groups (A and B).

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