Comparison of the effects of Tranexamic Acid and Vitamin K in the prevention of hemorrhage in TURP surgery.

Determining the Effect of Transxamic Acid and Vitamin K in Preventing Bleeding in TURP Surgery

Patients are divided into three groups of 25 people. The first group was given placebo (normal saline), the second group (tranexamic acid) and the third group were given vitamin K Clinical study of a randomized parallel, One-sided blind

Patients are divided into three groups of 25 people. The first group was given placebo (normal saline), the second group (tranexamic acid) and the third group were given vitamin K. The study is conducted at Khatam Al-Anbiya Hospital in Shahrood. Participants in the study are blind

Inclusion criteria: Male gender, age 60 to 90 years, satisfaction with conducting prostatectomy through the duct Exclusion criteria include coagulation disorder (hemophilia, VWD, ITP, factor 5 deficiency), liver disease (cirrhosis, hepatitis, liver cancer), anticoagulant drugs (warfarin, heparin, enoxaparin, plavix), heart patients (history of MI Last year, Class 3 and 4heart failure , and arrhythmia such as AF), history of stroke, thrombotic disease, age less than 60 years of nonprostatic action, and dissatisfaction with participating in the study

Patients are divided into three groups of 25 people. The first group was given placebo (normal saline), the second group (tranexamic acid) and the third group were given vitamin K

The incidence of hematuria, reduction in hemoglobin levels, changes in blood pressure

The computerized block randomization (block sizes of 3 and 9) will carried out in this study. An independent clinical epidemiologist, who will not involved in the conduct of the study used a computerized block randomization program (STATA14 software) uses to produce the allocation codes.The randomization sequences will be concealed in lightproof, sealed envelopes.The research assistant opened sealed, numbered, opaque envelopes containing allocation codes. The eligible participants will be randomized to three equal groups (normal saline group, transxamic acid group and vitamin K group) according to the randomization list after signing informed consent form.

Patients will not be aware of the type of medication they receive and the second executor of the research project will complete the questionnaire at the end of the treatment without knowledge of the three groups. Also the data will be analyzed without any information about group selection