Inclusion criteria:
Iranian patients
Age over 18 years old
Patients with diagnosis of AION; non-arteritic type
Exclusion criteria:
Pregnancy before or during study
Past medical history of cataract, glaucoma ( open or close angle ) congenital eye disease such as cloboma and involvement with disease effecting the central visual field of patient
Patients with past medication history of using fluoxetine or other psychological medications including antidepressants
Patients suffering from psychological disease
Patients who use medications including :arthemeter، astemizol, cisapride, eliglustat, goserelin, isocarboxazide, artemether, leuprolide, linezolid, lumefantrine, methylene blue, phenelzine, pimozide, procarbazine, selegiline, thioridazine, tranylcypromine
Patients diagnosed with immunologic and collagen vascular disease
Patients with symptoms of or diagnosed with giant cell arteritis and positive CRP more than 3+ or ESR more than 40
Trauma or surgery history of eyes
Duration between involvement and interview more than 3 weeks
Patients without compliance of using fluoxetine or disagrement of patient to continue accompanying the study
Involvement by glaucoma
Involvement by cataract
Change in depression questionnaire score lower than 1 score in comparison to first and forth visit ( means the poor compliance of patient that has not used fluoxetine
Death of patient