The comparison of three oral prophylactic drugs on success of inferior alveolar nerve block and post operative pain in patient with symptomatic irreversible pulpitis.

The aim of this study was to compare the efficacy of three oral anesthetics (Ibuprofen, Naproxen and Ketrolac) in the success of inferior alveolar nerve block and post operative pain in patients with irreversible symptomatic pulpitis referred to the department of Endodontics, Azad University Islamic of Tehran will be held in 1397.

Pragmatic, community based, parallel group, double blind, randomized controlled trial

This clinical trial is double blind (all drugs and the control group are prepared in the same manner and the evaluator is different from the prescriber of the drug). It is randomized (blocked) and controlled by the placebo.80 healthy patients were selected from patients referring to the Department of Endodontics, Islamic Azad University of Tehran, who required root canal treatment of 1st or 2ed mandibular molars with irreversible pulpitis. Patients with moderate to severe pain are included in the study. The pain level of these teeth before the root canal therapy is evaluated by a cold test and EPT based on the HP-VAS measurement criterion of more than 54. Patients are divided into four groups according to the randomized table: the first group received 500 mg of Naproxen, the second group received 10 mg Ketrolac, and the third group received 400 mg of ibuprofen and the oral control placebo group are prescribed. After an hour, anesthetizing is done.

Inclusion criteria: 1-symptomatic irreversible pulpitis 2-Healthy participant 3-First & second molar of mandible Exclusion criteria: 1-Systematic disease 2-Pregnancy and lactation 3-Taking analgesics in the last 12 hours 4-Allergic drugs 5-History of RCT 6-Periodontitis & PDL widening more than 1mm

Group 1: Naproxen 500 mg, Group 2: Ketrolac 10 mg, Group 3: Ibuprofen 400 mg, Control group: Placebo

Pain severity

The block randomization method is used to divide the subject into subgroups called blocks, then the individuals in each block are randomly assigned to treatment conditions. In this type of sampling, each member of the defined community There is an equal and independent chance to be present in the sample, meaning that independence is not the choice of a member in any way in choosing other members of the community. In this method, first we get the list of all the members, then we assign a score to each of them and use the random number table to select the required number. In the random numbers table, the random numbers of the randomly assigned drugs are categorized in each group. The randomization unit in this study is individual. To avoid the bias, cryptographic selection is used to prevent selected bias. In this study, for the patient to be blind, the capsules that are in shape, color, size, and weight are each other and the same as those of the placebo group, are used to both patient and patient of the contents of the capsules. Treatment applied and taken bias does not exist.

This is a double blind clinical trial. In this study, patients are blinded to practitioners of capsules that are in shape, color, size, and weight of each other and are similar to those of the placebo group, so that both the patient and the patient do not know the content of the capsules. Then, from the random numbers table, we put the drugs in different groups, and the four drugs are coded by the person not in the research, and the codes are not determined until the end of the study. So far, each drug has a code that is unknown to the patient and the content of the capsule, but the person outside the study knows that each code is the drug. After this stage, the assessor and, with the corresponding code, will be evaluated and analyzed. Their statistics. In the end, after obtaining information about each code and its alignment with drugs, information on the effects of each drug is identified. 1. researcher who prescribes drugs is blinded to the case & placebo medications due to all medications are encapsulated in identical size & shape capsules. 2. Patient is also blinded due to who does not know about the containing capsules. 3. outcome assessor is the main researcher who does not know about the prescribed medications. 4. statistician is absolutely blinded to prescription and assessment.

There is no further information

Only some part of data including age, gender, and post operative pain intensity would be shared

6 mount after publication

Researchers working in academic institutions

Academic dental teams can request documentation in collaboration with project researchers through the above mentioned communication paths.

Peyman Mehrvarzfar. contract Call 09194889838 and email p_mehrvarzfar@dentaliau.ac.ir

Written letter from the organ and educational and scientific institutes will be sent to the dental faculty of Islamic Azad University and will be sent to the competent authorities within 6 months after the approval of the competent authorities.