Ketamine is a safe an inexpensive drug and clinical experience shows that intravenous Ketamin can prevent intraoperative hypotension and stress and induce longer postoperative analgesia. In this study, we compared the hemodynamic and analgesic effects of low dose intravenous Ketamine + Midazolam and intravenous Midazolam alone, was given immediately after spinal anesthesia. 60 individuals aged 18 years and over with ASA (American Society for Anesthesiology) Class 1 or 2, were randomly assigned into two groups. Arterial pressures, heart rate values, adverse effects, the time of first request for postoperative analgesia, visual analogue pain scores, total analgesic consumptions at 24 h were recorded in all patients.
General information
Acronym
IRCT registration information
IRCT registration number:IRCT201101293468N4
Registration date:2011-04-04, 1390/01/15
Registration timing:retrospective
Last update:
Update count:0
Registration date
2011-04-04, 1390/01/15
Registrant information
Name
Mohammad Reza Hajiesmaeili
Name of organization / entity
Tehran University of Medical Sciences
Country
Iran (Islamic Republic of)
Phone
00983516227747-00983517232422
Email address
hajiesmaeili@ssu.ac.ir
Recruitment status
Recruitment complete
Funding source
Vice chancellor for research, Shahid Sadoughi University of Medical Sciences and Health Services
Expected recruitment start date
2010-04-21, 1389/02/01
Expected recruitment end date
2010-11-22, 1389/09/01
Actual recruitment start date
empty
Actual recruitment end date
empty
Trial completion date
empty
Scientific title
The investigation of hemodynamic effects of intravenous Ketamine after spinal anaesthesia for caesarean section
Public title
The investigation of hemodynamic effects of intravenous Ketamine after spinal anaesthesia for caesarean section
Purpose
Supportive
Inclusion/Exclusion criteria
Inclusion criteria: 1- ASA=1,2; 2- No hx of recent head rrauma; 3- NO hx of opium addiction; 4- NO hx of psychiatric drug consumption; 5- NO hx of hallucination; 6- NO hx of delirium; 7- NO hx of hypertension; 8- NO hx of ischemic heart disease; 9-NO hx of known hypersensitivity to study drug; 10- Elective cesarean; 11- age above 18 years. Exclusion criteria: 1- hypersensitivity to study drug; 2- need to additive dose of Ketamine; 3- unexpected event during surgery.
Age
From 18 years old
Gender
Female
Phase
2-3
Groups that have been masked
No information
Sample size
Target sample size:
60
Randomization (investigator's opinion)
Randomized
Randomization description
Blinding (investigator's opinion)
Double blinded
Blinding description
Placebo
Used
Assignment
Parallel
Other design features
Secondary Ids
empty
Ethics committees
1
Ethics committee
Name of ethics committee
Vice chancellor for research, Shahid Sadoughi University of Medical Sciences and Health Services,
Street address
Shahid Sadoughi University of Medical Sciences and Health Services