The aim of this study is comparison of vaginal versus sublingual Misoprostol in successful termination of pregnancy. This study will be done on 268 pregnant women admitted in Alzahra hospital-Rasht 2011-2012. Inclusion criteria are 12-24 weeks single pregnancy confirmed with certain LMP and < 20 weeks sonography.
Exclusion criteria is Known sensitivity to prostaglandins, previous caesarian section, vaginal bleeding and placenta previa, Parity > 3. Women randomly will be divided in two groups. One group will be treated with sublingual misoprostol and vaginal placebo and another group will be treated with vaginal misoprostol and sublingual placebo. The doses are given each 3 hours to 24 hours and if pregnancy isn’t terminated, another doses should be continued each 3 hours to 48 hours and then if pregnancy still isn’t terminated within 48 hours, other methods will be used such as high dose oxytocin or historotomy. Vital signs and side effects (such as nausea, headache, breast tenderness, diarrhea, chilling, fever frequency of needing to analgesics, vomiting) will be control every 3 hours and register. The main outcome is the time interval between drug using to pregnancy termination and second outcome is abortion within 24 hours, abortion within 48 hours, comparing the pain onset after drug using in two groups and comparing the side effects. Data will be evaluated with statistical methods. The time interval of drug therapy to pregnancy termination will be compare in both groups and data will be evaluated with statistical methods.