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Study aim
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Determining the effect of linear, step- wise and functional ultrafiltration profiling on hypotension during dialysis in patients with chronic renal failure
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Design
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clinical trial with a control group in format of Latin square design , one-sided blind, randomized
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Settings and conduct
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The intervention site is hemodialysis. unites. For all patients, 4 different ultrafiltration protocols will be implemented. Protocols 1 include linear profiles, protocol 2: stack profiles, protocol 3: functional profiles, protocol 4: fixed ultrafiltration profiles, each of which will run for each group for 2 weeks.For each protocol, 6 hemodialysis sessions are considered and patients undergo hemodialysis 3 times a week and 4 hours each time. Patients' blood pressure will be controlled at each session in 5 times: before hemodialysis, at the first hour, second hour, third hour and after hemodialysis in the half-sitting position of the patient's arm.
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Participants/Inclusion and exclusion criteria
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Getting end stage renal failure
Hemoglobin>10
History of dialysis 3 months at least
Dialysis 3 times a week
Systolic blood pressure above 100 mm Hg before dialysis
Not use anti-hypertensive medication 4 hours before dialysis
Exclusion criteria: Classes 3 and 4 of Heart Failure Hepatic Impairment
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Intervention groups
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32 patients will be randomly blocked into four groups. Each block contains the letters A, B, C, and D, which patients will randomly place in these blocks. Then, the four groups will receive four different treatment protocols. Subjects in Group A will first receive Protocol 1, then 2, 3, and 4. Group B receives protocol 2, then 3, 4 and 1. Group C will also receive protocols 3, 4, 1 and 2, respectively. Group D will receive protocol 4, then 3, 2, and 1.
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Main outcome variables
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Blood pressure