Comparision between administration of FSH plus HCG versus HCG alone for triggering ,in the results of ICSI

comparision between administration of FSH plus HCG verusus HCG alone for triggering, in the results of ICSI

Clinical trials with community based and pragmatic control group, with parallel groups,one blind, randomized.

This study was conducted as a randomized one blind clinical trial.Normoresponder women who are referred to the avicenna Infertility Center, are randomly divided into two groups of 40, between the end of 1997 and the beginning of 1998 who are candidates for ICSI cycles. . Starting ultrasound in the case of a thin endometrium and lack of vision of the ovarian follicle larger than 10 millimeters of the antagonist cycle begins. The initial dose of gonadotrophin is based on age, weight, ovarian reserve and previous response to COH, and ultrasound and the visit are performed 5 days later, and then every 3-2 days. Dosage adjustment is based on follicular growth. The drugs used to stimulate the gonal F and menopause ovaries.

Inclusion Criteria : Candidate entering the ICSI cycle, ages 19 to 41 years, BMI between 18 and 30 AFC greater than or equal to 5 on the third day of the cycle, FSH on the third day of the cycle is less than 12. exclusion criteria: Endometriosis Grade 3 and 4, Ovulation induction contraindications, Severe male factor infertility diagnosis, history of 2 or more previous IVF or ICSI cycles.

Infertile normoresponder Women Candidate ICSI Cycle,randomly divide in two 40 members groups.First group receive FSH with HCG at triggering time,second group receive only HCG.

From the degree of chemical pregnancy (βHCG positive), the rate of implantation (seeing a pregnancy sack in sonography) and the clinical pregnancy rate (seeing fetal heart rate in ultrasound) are examined.

Patients are divided into two equal groups (A and B) based on a randomized design with six blocks that are designed using random allocation software.

The study population, taking into account that in the general process of treatment of ICSI, multiple injections of injections (at least 6 days) and only the last injection in the study group receive an additional injection every day (from the same type of ampoule that was received daily from day before Have blinded themselves to what group, study or control are. Data analysis with group A and group B data analysis, so that information on intervention on the user group is not known.

non ethical