Evaluation of oral Glutamine administration on myocardial damage following non-st elevation myocardial infarction, Double blind randomized clinical trial study

Evaluation of glutamine administration on myocardial damage following non-st elevation myocardial infraction

The randomized clinical trial with the intervention and control group, parallel groups, double blinded

A randomized clinical trial that is performed on patients undergoing non-emergency myocardial infraction who are referred to Fatemeh Zahra Hospital in Sari. The population studied in this study includes all adult patients (aged 18-80) including men and women who have inclusion criteria for research. Patients and therapists are not aware of the type of drug contained in powders (glutamine, Avicel and starch), and only the researcher knows the code based on the code (code A or code B)

Inclusion criteria:Age over 18 years NSTEMI patients Normal function of liver, renal system, pulmonary system and thyroid Exclusion criteria:Emergency patients Serious water and electrolyte disorders Unwillingness to co-operate with the patient History of chronic lung, liver, kidney and thyroid diseases and heart failure Age over 80 years Pregnant and lactating women Patients who are hypersensitive to glutamine or who are banned in any way by their administration of glutamine Total Bilirubin more than 10 mg / dL Creatinine clearance less than 30 ml / min Absolute Absence of Intestinal Feeding

A total of 106 patients with open heart surgery candidates were randomly divided into two groups of 53. For the first group, 0.5 g / kg of glutamine is taken orally once a day, and for the control group, placebo (Avicel and starch powder) is added. The drug forms of placebo are prepared in terms of the appearance of glutamine.

Duration of admission to CCU, Duration of hospitalization, Mortality after MI

Random method and description of each method: simple randomization After determining the size of the sample, 106 people, 53 in the control group and 53 in the intervention group were considered. By co-ordinating medical records, this number was considered average for the duration of the appointment, and then the list of individuals was determined. The list was prepared based on the patients' turn-by-turn and then, using the random numbers table, the numbers of the control and intervention group were determined and compared to the coordination for the next steps

In the informed consent form, patients are told that they may receive glutamine or placebo (Avicel powder and starch). Therefore, patients are not aware of their treatment group. Since patients and therapists are not aware of the type of drug contained in powders (glutamine, Avicel and starch), only the researcher is aware of the powder on the package code (code A or code B).