The Effect of Low-Dose Intravenous Ketamine on prevention of post dural puncture headache in patients undergoing Cesarean delivery by spinal anesthesia

Determining the effect of low dose venous ketamine on prevention of headache after spinal anesthesia in patients undergoing elective cesarean section

This is a double-blind non-randomized clinical trial study in which 70 patients undergoing elective cesarean section with spinal anesthesia are studied.

The place of the study is the operation room and gynecology department of Vali-e-Asr Hospital in Birjand. Patients are unaware of the type of prescripted medication. Medications are provided in uniform syringes encoded by one of the operating room nurses who are not included in the study. After doing spinal anesthesia and approximately 5 Minutes before the start of the procedure, the patients in the case group received 0.15 mg / kg body weight of ketamine administered intravenously, and in the control group, normal saline are used as placebo. In both groups, the incidence of headache, itching and nausea and severity at 1, 4, 12, and 24 hours after surgery are measured.

Inclusion criteria: informed consent, grades ASA 1-2, no history of migraine or other types of headaches, psychological problems, coagulation disorders and addiction. In case of unwanted complications like allergic reactions, respiratory complications, severe bleeding, bronchospasm, change in type of anesthesia, and more than one attempt to produce spinal anesthesia, the patient is excluded from the study.

Intervention group: receiving intravenous ketamine Control group: receiving normal saline

Headache, nausea and itching

Patients are not aware of the type of prescribed medications which are in uniform syringes encoded by one of the operating room nurses who are not in the study. The investigator is not informed about the groups until the end of the data collection.