The effect of glutamine mouthwash in prevention of mucositis following the administration of high doses of methotrexate in children with acute lymphoblastic leukemia

The study of the effect of oral glucose in prevention of mucositis, following a high dose of methotrexate in children with acute lymphoblastic leukemia

Based on the statistics advice and based on previous studies, 100 patient-episodes are studied. They are divided into two groups of 50 cases or control according to the random numbers table.

For the patient, starting with the 24-hour infusion, methotrexate is given every 8 hours for mouthwash and at least 30 seconds for oral mouthwash. In the control group, the patient receives a standardized oral mucosa (containing 100,000 units nystatin per cc + diphenhydramine 2.5 mg per cc + 260 cc MG aluminum syrup). The case group in each patient-the mouthpiece episode in the same container containing the above plus 16 grams in 260 cc of glutamine is used similarly. Patients are not aware of the type of mouthwash in each patient-episode. .

Inclusion criteria: Age of 5 to 10 years, ALL,treated by high dose of methotrexate, no mucositis before receiving methotrexate, no nausea and vomiting before starting methotrexate exclusion criteria:presence of fever, use of systemic or topical antibiotics

Patients from 5 to 10 years old children with ALL who are admitted and treated in the blood and cancer boolea group are treated with a high dose of intravenous methotrexate (5 g / 24 hours infusion) in the Interim maintenance 1 protocol. Placed.

Sex، Age، The presence of mucositis، Mucositis intensity، Mucositis period، Number of nausea، The number of vomiting times، Number of feeds of fluids، The frequency of feeding solids

After observing the inclusion criteria, a number is assigned to each patient at each time of drug administration. Then, based on the table of random numbers, the individual numbers in the control group and even numbers are placed in the case group.

Each patient will be informed by the dentist prior to receiving the drug in terms of the severity and severity of the mucositis. The dentist will not be aware of the patient who is rejected (case or control). For the patient, starting with the 24-hour infusion, methotrexate is given every 8 hours for mouthwash and at least 30 seconds for oral mouthwash.In the control group, the patient receives a standard oral mucosa (containing 100,000 units of nystatin in a cc + diphenhydramine 2.5 mg per cc + 260 cc of MG aluminum syringe). The case group in each patient uses the same oral mucosal epizood in the same container containing the above plus 16 grams in 260 cc of glutamine, The above mouthwash is prepared in coordination with the pharmacy department of the pharmacy of Bu Ali Hospital in Sari and under the supervision of the pharmacist's colleague, Dr. Sahraei. Patients are not aware of the type of mouthwash in each patient-episode The nurse in the oncology department monitors the proper use of mouthwash and, if not properly used, to be excluded from the study.