Anti-Inflammatory Effects of Vitamin D and Resistance Training in Men with Type 2 Diabetes mellitus and Vitamin D Deficiency

The study aimed to investigate the anti-inflammatory effects of vitamin D and resistance training in men with type 2 diabetes mellitus and vitamin D deficiency.

Forty eight men were randomly divided into four groups including; vitamin D supplements and resistance training group, resistance training group, vitamin D supplementation group, or control group. The trial had a control group, a community-based, factorial double-blinded groups, and simple randomization using random numbers table.

This research was conducted in Ardabil city and among type 2 diabetic patients referred to the Diabetes Association of the city. Before and after 12 weeks, blood samples were taken to examine the inflammatory factors of the subjects. Bleeding was done until the end of the intervention for researchers, biochemical laboratory technicians, statisticians, subjects and all testers except one person.

The participants were forty-eight inactive people aged 40-65 who had symptoms of diabetes. Inclusion Criteria: The fasting blood glucose level was higher than 126 mg/dL, HbA1c was less than 9%, and the symptoms of vitamin D deficiency with 25 hydroxyvitamin D were less than 20 ng/ml. Exclusion criteria: People with kidney, cardiovascular, liver and other chronic diseases, as well as patients with a history of regular exercise with a history of supplementation with vitamin D and calcium

Intervention group 1: Vitamin D and resistance training, intervention group 2: resistance training, intervention group 3: vitamin D supplementation group and intervention group 4: control group

Main outcome variables In this study, systemic inflammatory indexes included some interleukins and C-reactive protein. The effect of 12 weeks of exercise training and vitamin D supplements on them was investigated.

Depending on the number of subjects and groups, it was decided to divide the groups by simple random method and in an individually style. In that, random numbers table were used to divide the equal groups. Random sequences were also used to allocation concealment groups from non-transparent, sealed envelopes. The randomization process was carried out by researchers and two assistants, but the researchers did not know the type of each group. Specifically, vitamin and placebo groups were blamed for researchers.

lab technicians and expert statisticians did not know the type of intervention of any of the groups. Subjects and researchers also blinded to vitamin and placebo groups. Capsules containing vitamins and placebo were similar and only one of the practitioner's help was able to relate to the content of vitamin and placebo, and supplement giving was done by this person. He had a list of people in the groups that provided them with the capsules. This blindness continued until the end of the intervention and analysis of the data.

Exercise training and supplementation protocols and Initial consequences

2019-2020

All

Use of data and results to improve the status of diabetic patients

Islamic Azad University of Sanandaj website and the Center for Clinical Trials Registration (IRCT)

Refer to the above sites