The effects aerobic training and resveratrol supplementation on oxidative stress in women with metabolic syndrome

• Comparison of the mean age, weight, height, BMI and blood pressure in each group and between the study groups before and after intervention, and comparison of mean changes between groups • Comparison of mean serum malondialdehyde in each group and between the study groups before and after intervention, and comparison of mean changes between groups • Comparison of mean serum total antioxidant capacity in each group and between the study groups before and after intervention, and comparison of mean changes between groups

The present study is a phase 3 clinical trial with control group, parallel groups, double blind and randomized. in this study, 32 female with metabolic based on inclusion criteria and Permuted Block Randomization method randomly using random number table divided to 4 groups included aerobic training group, resveratrol supplement group, aerobic training + resveratrol group and control group.

The first group received 3 sessions (60 min) exercise and resveratrol placebo (oral paraffin 400 mg/Day), second group resveratrol 400 mg/day, the third group aerobic exercise + resveratrol, and fourth group resveratrol placebo for 8 weeks. Sampling perform from mokhaberat club in Tehran.

Inclusion criteria: Being female; Age 18-50 years; Body Mass Index 18.5-29.9; patients with metabolic syndrome; No any other chronic diseases; no taking any drugs or special physical activity Exclusion criteria: Allergic reaction to resveratrol; pregnancy during the study; any changes in usual diet and life style or intake of multivitamin supplementation; withdrawal of the patient for cooperation

1) Aerobic training group 2) Resveratrol supplement group 3) Aerobic training + resveratrol supplement group 4) Control group

Malondyaldeid serum level Total anti-oxidant capacity serum level

Patients were divided into 4 groups evenly using Permuted Block Randomization. Then, based on the blocks that were randomly assigned using the random number table, the order of the intervention was determined.

Supplements were coded by a third person and given to participants in a same form package. None of the participants and researchers were aware of the allocation of groups.

In addition to data on the main outcome of the study (oxidative stress), the baseline data of participants (such as demographic and anthropometric data) will shared after blinding.

Start the access 6 months after publishing the results

The results of present study will be available to academic researcher and pharmaceutical companies in order to supplement production.

The data of present study can be used for review, systematic review and meta-analysis articles.

Applicants can access to study results trough e-mail to a scientist responsible for the study: Dr. Mina Abdolahi Email: abdolahimina.n@gmail.com

Through sites which the manuscript will indexed, through research gate site and e-mail to scientist responsible for the study (Dr. Mina Abdolahi)