Study of the effect of vitamin D oral supplementation on glycemic control, serum levels of growth hormone, insulin-like growth factor-1 and lipid profile in gestational diabetes mellitus patients

The purpose of this study is to determine the effect of Vitamin D oral supplementation on glycemic control, serum levels of Growth Hormone, Insulin-Like Growth Factor-1 and Lipid Profile in Gestational Diabetes Mellitus patients

This is a randomized, double-blind, placebo-controlled clinical trial. The final sample includes 30 gestational diabetes patients who have been selected by convenience sampling method and will be placed randomly in two groups of intervention (n=15) and control (n=15). This study will be done within 6 weeks.

At the baseline and the end of study, blood samples will be collected and the growth hormone, Insulin-like growth factor-1, lipid profile and glycemic status in patients will be compared before and after the intervention.

Inclusion criteria: detection of Gestational Diabetes Between 24-28 weeks of pregnancy, tend to participate in the study, age category between 18-40 years old, consumption of daily multivitamins; Exclusion criteria: twin or multiple pregnancy, having a Body Mass Index greater than 40, consumption of Vitamin D supplementation at least three months before the intervention, consumption of Insulin or Metformin, people with cardiovascular diseases, digestive disorders, hypertension, inflammatory diseases and hypothyroidism due to the effect on insulin metabolism and lipid profile.

The intervention group will receive one tab containing 2000 IU vitamin D3 daily for 6 weeks; The control group will receive one plasebo containing paraffin oil daily for 6 weeks.

Vitamin D, growth hormone, insulin like growth factor-1, glucose, insulin, Cholesterol, triglyceride

Words of "intervention" and "control" will be writen on the 30 sheets and will be placed in Sealed envelope. Each patient will be asked to pick a envelope randomly.

This study is a double blinded clinical trial that participants are randomly classified into two groups of intervention and control and none of them know in which group they are. Researchers are unaware which participants are receiving the real treatment.