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Study aim
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Determining the effect of combined oral supplementation vitamin D, zinc, calcium, and magnesium on glycemic control profiles, lipid profiles, liver enzymes, serum CRP in type 2 diabetic patients
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Design
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A controlled clinical trial, double-blind, randomized, Stratified block randomization, two groups of 39 people for involvement in two months
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Settings and conduct
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Patients who referred to the clinic, if they wished, completed the consent form, then received food with a 24-hour three-day recall, physical activity, and blood samples, and supplemented by a third person outside the study, and After two months, these tests will be taken
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Participants/Inclusion and exclusion criteria
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Entrance: Over the age of 18 and under the age of 65, people with diabetes who take the same drugs like metformin, glibenclamide, metformin-repaglantine.
Exit: Pregnant and lactating people, smoking and alcohol, people with polycystic ovary syndrome,
History of or suffering from heart disease and cancer, gastrointestinal diseases, history of malabsorption surgery, hormone therapy, diabetic foot ulcer and ...
Consumption of any supplements up to three months before the study, changes in the medications used during the intervention
, Changes in physical activity during the study
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Intervention groups
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The experimental group was 39 patients and the control group 39, followed by two months of intervention, in the supplementation group supplemented with 200 units of vitamin D 4 mg zinc oxide, 100 mg of magnesium oxide and 400 mg of calcium In the form of carbonate and in the placebo control group, this supplement, which is a combination, will receive sorbitol Caryon.
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Main outcome variables
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Zinc, insulin sensitivity, insulin resistance, fasting insulin, HbA1c, fasting glucose, lipid profile, CRP inflammatory index, liver enzymes