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Study aim
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Determining the effect of low dose aspirin on clinical pregnancy rate in frozen-thawed embryo transfer cycles.
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Design
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Randomized clinical trial with case group and control group with parallel therapies
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Settings and conduct
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This study is carried out at Yazd Research and clinical Center for Infertility (Research Institute for Reproductive Sciences). Patients in frozen-thawed embryo transfer cycle are divided into case and control groups. In the case group, 6 mg of estradiol valerate (oral estradiol valerate 2 mg every eight hours) and 1 mg of folic acid and 80 mg of aspirin are prescribed daily. In the control group, 6 mg of estradiol valerate and 1 mg of folic acid are prescribed daily.
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Participants/Inclusion and exclusion criteria
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In this study, 130 infertile women included based on inclusion criteria: age between 18 to 40 years old, at least two embryos transferable in a frozen-thawed cycle, no history of uterine surgery or anomalies, and uterine adhesions, no history of repeated abortions, no history of endometriosis, and absence of contraindication for aspirin use (which are candidates for embryo transfer in frozen-thawed cycles is randomly divided into two groups (A, 65, and B, 65 controls). Patients with oocyte donation and untreated thyroid disorders excluded from study
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Intervention groups
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In the case group, for the preparation of the endometrium, in addition to the tablet of estradiol valerate and folic acid, aspirin tablets (80 mgstart) start from the previous cycle. In the control group only estradiol valrate and folic acid are prescribed.
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Main outcome variables
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Endometrial thickness is measured on day 13 of cycle . On the transfer day , Endometrial thickness is measured in both groups.
Chemical pregnancy is investigated 14 days after embryo transfer by beta-hCG test and, if it was positive two weeks later, clinical pregnancy checked by fetal hearth rate in sonography.