Protocol summary

Study aim
The purpose of this study was to investigate the effect of resistance exercise with concentric failure sets and configuration cluster sets on response of cardiovascular, bio markers of cardiac injury,left and right ventricles mechanical mechanism of athletic myocardium and performance.
Design
Cross-sectional analysis of clinical trials was performed. SPSS Simple Random Sampling using to selected 24 cases and with limited random block allocations 6 cases in 4 blocks. The concealment was done in two blinding form. Clinical trials are classified into one phase.
Settings and conduct
training protocol performing in Gym of University of Tehran Dormitory and the tests taking in Shahid Rajaee Heart Center, On the day of the exercise protocol performing, None of the subjects or tester have aware of which of the two protocols performing.
Participants/Inclusion and exclusion criteria
Inclusion criteria: athletes with a history of weight training in advanced level with absence of any disease, not taking any kind of exercise supplement Exclusion criteria: Training history less than 3 years, No regular weight training in the past 18 months, absence of clinical symptoms associated with cardiovascular disease and musculoskeletal disorders and diseases, not taking ergogenic supplements for at least 8 weeks before the test.
Intervention groups
intervention 1 (INT1) : concentric failure sets with intensity zone 12-15 repetition maximum (RM) in 3 sets volume, INT2: same with INT1 but intensity (8-10 RM),INT3: configuration cluster sets with intensity (8-10 RM) in 9 sets volume with 2 to 3 reps, INT4: configuration cluster sets with intensity (12-15 RM) in 9 sets volume with 4 to 5 reps.
Main outcome variables
high sensitivity Cardiac Troponin I, N-terminal proBNP , right and left ventricular end systolic and diastolic volume and dimension.Right and left Ventricular Global Longitudinal Strain

General information

Reason for update
Acronym
IRCT registration information
IRCT registration number: IRCT20190403043158N1
Registration date: 2020-09-27, 1399/07/06
Registration timing: retrospective

Last update: 2020-09-27, 1399/07/06
Update count: 0
Registration date
2020-09-27, 1399/07/06
Registrant information
Name
azizeh ahmadi
Name of organization / entity
The university of tabriz
Country
Iran (Islamic Republic of)
Phone
+98 21 6697 5985
Email address
azizeh.ahmadi@tabrizu.ac.ir
Recruitment status
Recruitment complete
Funding source
Expected recruitment start date
2018-11-11, 1397/08/20
Expected recruitment end date
2019-05-10, 1398/02/20
Actual recruitment start date
2018-11-22, 1397/09/01
Actual recruitment end date
2019-06-18, 1398/03/28
Trial completion date
2019-06-18, 1398/03/28
Scientific title
The effect of two type resistance exercise, concentric failure set and configuration cluster sets on bio markers of myocardium injury and left and right ventricles mechanical mechanism in athletic
Public title
The effect of high intensity resistance exercise on the biological and mechanical mechanism of the heart
Purpose
Health service research
Inclusion/Exclusion criteria
Inclusion criteria:
Everyone with a history of weight training in advanced level People who have regular weight training during the weekly exercise program. People with absence of any disease Not taking any kind of exercise supplement
Exclusion criteria:
Training history less than 3 years No regular weight training in the past 18 months Absence of clinical symptoms associated with cardiovascular disease Not taking ergogenic supplements for at least 8 weeks before the test Absence of musculoskeletal disorders and diseases
Age
From 20 years old to 27 years old
Gender
Male
Phase
N/A
Groups that have been masked
  • Participant
  • Outcome assessor
  • Data analyser
Sample size
Target sample size: 24
Actual sample size reached: 24
Randomization (investigator's opinion)
Randomized
Randomization description
24 male strength athletes were selected by simple random sampling using SPSS software and from data select cases.Each subject was given a four-digit numeric code (for example: 1248) through which the code number was identified. In order to allocate sequences and able to control the number of subjects in each group, a limited randomized block allocation method was used. 24 subjects were placed in 4 blocks with setting a block size of 6, By applying the factorial formula, 6 possible combination were identified. , to determine the block number assigning 6 cases per block,used spss software with from the path Transform / Compute Variable / BLOCK_NUM / RND ($ CASENUM / 4 + 0.49). $ CASENUM / 4 indicates the case number divided by 4. Then random allocation group numbers were applied to all 6 possible combination. Which was done through: Transform / Rank cases / RANDOM / BLOCK_NUM. The concealment allocation was done through sealed the number of coded. Both the subject and the test taker until the moment of implementation do not be aware of the sequence generation step.
Blinding (investigator's opinion)
Double blinded
Blinding description
On the day that the exercise protocol was performed, None of the subjects or tester were aware of which of the two protocols were performed.Before the intervention subjects were not aware of the which intensity and type of resistance exercise will be performed.The persons responsible for measuring and analyzing the dependent variables of the research did not know which intervention method was implemented.
Placebo
Not used
Assignment
Parallel
Other design features

Secondary Ids

empty

Ethics committees

1

Ethics committee
Name of ethics committee
Ethics committee of Tabriz University of Medical Sciences
Street address
No. 111, Al-Ghadir Building, next to Faculty of Engineering, Amir Abad, North Kargar Ave, Tehran
City
Tehran
Province
Tehran
Postal code
1439951154
Approval date
2018-03-12, 1396/12/21
Ethics committee reference number
IR.TBZMED.REC.1396.1166

Health conditions studied

1

Description of health condition studied
The bio markers of cardiac injury response to two type resistance exercise, concentric failure set and configuration cluster sets
ICD-10 code
ICD-10 code description

2

Description of health condition studied
The response of left ventricles mechanical mechanism of athletic myocardium to two type resistance exercise, concentric failure set and configuration cluster sets
ICD-10 code
ICD-10 code description

3

Description of health condition studied
The response of right ventricles mechanical mechanism of athletic myocardium to two type resistance exercise, concentric failure set and configuration cluster sets
ICD-10 code
ICD-10 code description

4

Description of health condition studied
The response of blood pressure after the two type resistance exercise, concentric failure set and configuration cluster sets
ICD-10 code
ICD-10 code description

Primary outcomes

1

Description
Heart Ventricles dysfunction
Timepoint
Before and during the intervention, after 30 min, 4, 6, 12 and 24 hours after intervention
Method of measurement
Philips EPIQ7 Echocardiography, hscTnI and Nt-proBNP with PATHFAST system, REAGENT KITS FOR CRITICAL CARE DIAGNOSTICS (LSI Medience Corporation 13-4, Uchikanda 1-chome, Chiyoda-ku Tokyo 101-8517 JAPAN).

Secondary outcomes

1

Description
Rate of Perceived Exertion (RPE).
Timepoint
Before and during the intervention, after 30 min.
Method of measurement
Borg's 6–20 RPE (Rating of Perceived Exertion) scale

2

Description
Hand grip strength
Timepoint
Before and during the intervention, after 30 min.
Method of measurement
Yagami YG-200, Tokyo, Japan.

3

Description
Heart rate
Timepoint
Before and during the intervention, after 30 min, 4, 6, 12 and 24 hours after intervention
Method of measurement
Heart Rate monitor Polar v800, ECG connection to Philips EPIQ7 Echocardiography,

4

Description
Systolic blood pressure
Timepoint
Before the intervention, after 30 min, 4, 6, 12 and 24 hours after intervention.
Method of measurement
Finometer PRO (Finapress Medical Systems BV, Amsterdam, the Netherlands)

5

Description
Diastolic blood pressure
Timepoint
Before the intervention, after 30 min, 4, 6, 12 and 24 hours after intervention.
Method of measurement
Finometer PRO (Finapress Medical Systems BV, Amsterdam, the Netherlands)

6

Description
Systemic vascular resistance
Timepoint
Before the intervention, after 30 min, 4, 6, 12 and 24 hours after intervention.
Method of measurement
Finometer PRO (Finapress Medical Systems BV, Amsterdam, the Netherlands)

7

Description
Mean blood pressure
Timepoint
Before the intervention, after 30 min, 4, 6, 12 and 24 hours after intervention.
Method of measurement
Finometer PRO (Finapress Medical Systems BV, Amsterdam, the Netherlands)

8

Description
Haematocrit
Timepoint
Before and during the intervention, after 30 min, 4, 6, 12 and 24 hours after intervention
Method of measurement
ELISA test

9

Description
Albumin
Timepoint
Before and during the intervention, after 30 min, 4, 6, 12 and 24 hours after intervention
Method of measurement
ELISA test

10

Description
Cortisol
Timepoint
Before and during the intervention, after 30 min, 4, 6, 12 and 24 hours after intervention
Method of measurement
ELISA test

11

Description
C-reactive protein
Timepoint
Before and during the intervention, after 30 min, 4, 6, 12 and 24 hours after intervention
Method of measurement
ELISA test

12

Description
Serum electrolyte concentrations (Calcium)
Timepoint
Before and during the intervention, after 30 min, 4, 6, 12 and 24 hours after intervention
Method of measurement
ELISA test

13

Description
Serum electrolyte concentrations(Magnesium)
Timepoint
Before and during the intervention, after 30 min, 4, 6, 12 and 24 hours after intervention
Method of measurement
ELISA test

14

Description
Serum electrolyte concentrations(Potassium )
Timepoint
Before and during the intervention, after 30 min, 4, 6, 12 and 24 hours after intervention
Method of measurement
ELISA test

15

Description
Serum electrolyte concentrations (Sodium)
Timepoint
Before and during the intervention, after 30 min, 4, 6, 12 and 24 hours after intervention
Method of measurement
ELISA test

16

Description
high sensitivity Cardiac Troponin I (hscTnI)
Timepoint
Before the intervention, after 30 min, 4, 6, 12 and 24 hours after intervention
Method of measurement
hscTnI with PATHFAST system, REAGENT KITS FOR CRITICAL CARE DIAGNOSTICS (LSI Medience Corporation 13-4, Uchikanda 1-chome, Chiyoda-ku Tokyo 101-8517 JAPAN).

17

Description
N-terminal proBNP (NT-proBNP)
Timepoint
Before the intervention, after 30 min, 4, 6, 12 and 24 hours after intervention
Method of measurement
NT-proBNP with PATHFAST system, REAGENT KITS FOR CRITICAL CARE DIAGNOSTICS (LSI Medience Corporation 13-4, Uchikanda 1-chome, Chiyoda-ku Tokyo 101-8517 JAPAN).

18

Description
Left ventricular end systolic volume and dimension
Timepoint
Before and during the intervention, after 30 min, 4, 6, 12 and 24 hours after intervention
Method of measurement
Two-dimensional (2D) heart echo, Philips EPIQ7 Echocardiography

19

Description
Left ventricular end diastolic volume and dimension
Timepoint
Before and during the intervention, after 30 min, 4, 6, 12 and 24 hours after intervention
Method of measurement
Two-dimensional (2D) heart echo, Philips EPIQ7 Echocardiography

20

Description
Stroke volume
Timepoint
Before and during the intervention, after 30 min, 4, 6, 12 and 24 hours after intervention
Method of measurement
Two-dimensional (2D) heart echo, Philips EPIQ7 Echocardiography

21

Description
Cardiac output
Timepoint
Before and during the intervention, after 30 min, 4, 6, 12 and 24 hours after intervention
Method of measurement
Two-dimensional (2D) heart echo, Philips EPIQ7 Echocardiography

22

Description
Ejection Fraction
Timepoint
Before and during the intervention, after 30 min, 4, 6, 12 and 24 hours after intervention
Method of measurement
Two-dimensional (2D) heart echo, Philips EPIQ7 Echocardiography

23

Description
Left ventricle posterior wall thickness in diastole
Timepoint
Before and during the intervention, after 30 min, 4, 6, 12 and 24 hours after intervention
Method of measurement
Two-dimensional (2D) heart echo, Philips EPIQ7 Echocardiography

24

Description
Right ventricular end systolic dimension
Timepoint
Before and during the intervention, after 30 min, 4, 6, 12 and 24 hours after intervention
Method of measurement
Two-dimensional (2D) heart echo, Philips EPIQ7 Echocardiography

25

Description
Right ventricular end diastolic dimension
Timepoint
Before and during the intervention, after 30 min, 4, 6, 12 and 24 hours after intervention
Method of measurement
Two-dimensional (2D) heart echo, Philips EPIQ7 Echocardiography

26

Description
Right Ventricular Global Longitudinal Strain (RVGLS)
Timepoint
Before and during the intervention, after 30 min, 4, 6, 12 and 24 hours after intervention
Method of measurement
Two-dimensional (2D) heart echo, Philips EPIQ7 Echocardiography

27

Description
Posterior Wall Thickness (PWT), Relative Wall Thickness (RWT) , Inter Ventricular Septum Thickness (IVST)
Timepoint
Before and during the intervention, after 30 min, 4, 6, 12 and 24 hours after intervention
Method of measurement
Two-dimensional (2D) heart echo, Philips EPIQ7 Echocardiography

28

Description
Left Ventricular Mass Indexed (LVMI)
Timepoint
Before and during the intervention, after 30 min, 4, 6, 12 and 24 hours after intervention
Method of measurement
Two-dimensional (2D) heart echo, Philips EPIQ7 Echocardiography

29

Description
Duration of Deceleration (DT) in blood flow from the atrium to the left ventricle in the early phase of diastole: E-wave DT
Timepoint
Before and during the intervention, after 30 min, 4, 6, 12 and 24 hours after intervention
Method of measurement
Two-dimensional (2D) heart echo, Philips EPIQ7 Echocardiography

30

Description
Right Ventricular Longitudinal Strain (RVLS)
Timepoint
Before and during the intervention, after 30 min, 4, 6, 12 and 24 hours after intervention
Method of measurement
Two-dimensional (2D) heart echo, Philips EPIQ7 Echocardiography

31

Description
Right ventricular free wall longitudinal strain
Timepoint
Before and during the intervention, after 30 min, 4, 6, 12 and 24 hours after intervention
Method of measurement
Two-dimensional (2D) heart echo, Philips EPIQ7 Echocardiography

32

Description
Right ventricular global circumferential strain
Timepoint
Before and during the intervention, after 30 min, 4, 6, 12 and 24 hours after intervention
Method of measurement
Two-dimensional (2D) heart echo, Philips EPIQ7 Echocardiography

33

Description
Right ventricular free wall circumferential strain
Timepoint
Before and during the intervention, after 30 min, 4, 6, 12 and 24 hours after intervention
Method of measurement
Two-dimensional (2D) heart echo, Philips EPIQ7 Echocardiography

34

Description
Right ventricular septal circumferential strain
Timepoint
Before and during the intervention, after 30 min, 4, 6, 12 and 24 hours after intervention
Method of measurement
Two-dimensional (2D) heart echo, Philips EPIQ7 Echocardiography

35

Description
Right ventricular septal longitudinal strain
Timepoint
Before and during the intervention, after 30 min, 4, 6, 12 and 24 hours after intervention
Method of measurement
Two-dimensional (2D) heart echo, Philips EPIQ7 Echocardiography

36

Description
Early diastolic myocardial relaxation (E′)
Timepoint
Before and during the intervention, after 30 min, 4, 6, 12 and 24 hours after intervention
Method of measurement
Two-dimensional (2D) heart echo, Philips EPIQ7 Echocardiography

37

Description
Left ventricular filling pressure: ratio E/e′
Timepoint
Before and during the intervention, after 30 min, 4, 6, 12 and 24 hours after intervention
Method of measurement
Two-dimensional (2D) heart echo, Philips EPIQ7 Echocardiography

38

Description
Peak blood flow in the early phase of diastole (E)
Timepoint
Before and during the intervention, after 30 min, 4, 6, 12 and 24 hours after intervention
Method of measurement
Two-dimensional (2D) heart echo, Philips EPIQ7 Echocardiography

39

Description
Peak blood flow velocity in diastolic delay phase (A)
Timepoint
Before and during the intervention, after 30 min, 4, 6, 12 and 24 hours after intervention
Method of measurement
Two-dimensional (2D) heart echo, Philips EPIQ7 Echocardiography

40

Description
Flow to injection ratio;Ratio of blood flow from mitral valve to blood transfusion from atrium, ratio E/A
Timepoint
Before and during the intervention, after 30 min, 4, 6, 12 and 24 hours after intervention
Method of measurement
Two-dimensional (2D) heart echo, Philips EPIQ7 Echocardiography

41

Description
Peak systolic velocity of the Tricuspid annulus
Timepoint
Before and during the intervention, after 30 min, 4, 6, 12 and 24 hours after intervention
Method of measurement
Two-dimensional (2D) heart echo, Philips EPIQ7 Echocardiography

42

Description
Left ventricular relaxation in early diastolic
Timepoint
Before and during the intervention, after 30 min, 4, 6, 12 and 24 hours after intervention
Method of measurement
Two-dimensional (2D) heart echo, Philips EPIQ7 Echocardiography

43

Description
Right ventricular myocardial performance index
Timepoint
Before and during the intervention, after 30 min, 4, 6, 12 and 24 hours after intervention
Method of measurement
Two-dimensional (2D) heart echo, Philips EPIQ7 Echocardiography

44

Description
Fractional Area Change (FAC)
Timepoint
Before and during the intervention, after 30 min, 4, 6, 12 and 24 hours after intervention
Method of measurement
Two-dimensional (2D) heart echo, Philips EPIQ7 Echocardiography

45

Description
Tricuspid annular plane systolic excursion (TAPSE)
Timepoint
Before and during the intervention, after 30 min, 4, 6, 12 and 24 hours after intervention
Method of measurement
Two-dimensional (2D) heart echo, Philips EPIQ7 Echocardiography

46

Description
Systolic pulmonary artery pressure (SPAP)
Timepoint
Before and during the intervention, after 30 min, 4, 6, 12 and 24 hours after intervention
Method of measurement
Two-dimensional (2D) heart echo, Philips EPIQ7 Echocardiography

47

Description
Tricuspid Regurgitant Gradient (TRG)
Timepoint
Before and during the intervention, after 30 min, 4, 6, 12 and 24 hours after intervention
Method of measurement
Two-dimensional (2D) heart echo, Philips EPIQ7 Echocardiography

48

Description
Left ventricular global longitudinal strain (LVGLS)
Timepoint
Before and during the intervention, after 30 min, 4, 6, 12 and 24 hours after intervention
Method of measurement
Two-dimensional (2D) heart echo, Philips EPIQ7 Echocardiography

49

Description
Left ventricular circumferential strain
Timepoint
Before and during the intervention, after 30 min, 4, 6, 12 and 24 hours after intervention
Method of measurement
Two-dimensional (2D) heart echo, Philips EPIQ7 Echocardiography

50

Description
Left ventricular longitudinal strain
Timepoint
Before and during the intervention, after 30 min, 4, 6, 12 and 24 hours after intervention
Method of measurement
Two-dimensional (2D) heart echo, Philips EPIQ7 Echocardiography

51

Description
Left ventricular relaxation in early diastole (septal and lateral)
Timepoint
Before and during the intervention, after 30 min, 4, 6, 12 and 24 hours after intervention
Method of measurement
Two-dimensional (2D) heart echo, Philips EPIQ7 Echocardiography

52

Description
Ratio of Early to late filling velocity left ventricular (E/A ratio)
Timepoint
Before and during the intervention, after 30 min, 4, 6, 12 and 24 hours after intervention
Method of measurement
Two-dimensional (2D) heart echo, Philips EPIQ7 Echocardiography

53

Description
Early diastolic left ventricular tissue velocity
Timepoint
Before and during the intervention, after 30 min, 4, 6, 12 and 24 hours after intervention
Method of measurement
Two-dimensional (2D) heart echo, Philips EPIQ7 Echocardiography

54

Description
Left ventricular mass
Timepoint
Before and during the intervention, after 30 min, 4, 6, 12 and 24 hours after intervention
Method of measurement
Two-dimensional (2D) heart echo, Philips EPIQ7 Echocardiography

Intervention groups

1

Description
Intervention 1: concentric failure sets with circuit pattern consist of 9 movements: in front squat, bench press, dead lift, shoulder press, in front lunge, weight pull up, roman lift, weight dip parallel and bent over row with intensity zone (12-15 RM) in three sets of 12 to 15 repetitions with 120 seconds rest interval between each movement or set.
Category
Other

2

Description
Intervention 2: concentric failure sets with circuit pattern consist of 9 movements: in front squat, bench press, dead lift, shoulder press, in front lunge, weight pull up, roman lift, weight dip parallel and bent over row with intensity zone (8-10 RM) in three sets of 8 to 10 repetitions with 120 seconds rest interval between each movement or set
Category
Other

3

Description
Intervention 3: configuration cluster sets with circuit pattern consist of 9 movements: in front squat, bench press, dead lift, shoulder press, in front lunge, weight pull up, roman lift, weight dip parallel and bent over row with intensity zone (12-15 RM) in nine sets of 4 to 5 repetitions with 40 seconds rest interval between each movement or set
Category
Other

4

Description
Intervention 4: configuration cluster sets with circuit pattern consist of 9 movements: in front squat, bench press, dead lift, shoulder press, in front lunge, weight pull up, roman lift, weight dip parallel and bent over row with intensity zone (8-10 RM) in nine sets of 2 to 3 repetitions with 40 seconds rest interval between each movement or set
Category
Other

Recruitment centers

1

Recruitment center
Name of recruitment center
University of Tehran Faculty of Physical Education and Sport Sciences
Full name of responsible person
Rasoul Dokht Abdiyan
Street address
Faculty of Physical Education and Sport Sciences, between 15th and 16th St., North Kargar st., Tehran, Islamic Republic
City
Tehran
Province
Tehran
Postal code
1439951154
Phone
+98 21 8835 1730
Email
infosport@ut.ac.ir
Web page address
http://sport.ut.ac.ir/

Sponsors / Funding sources

1

Sponsor
Name of organization / entity
Vice chancellor for research, Faculty of Tehran University, Physical Education and Sport Sciences
Full name of responsible person
Foad Seyedi
Street address
Faculty of Tehran University,Physical Education and Sport Sciences, between 15th and 16th St., North Kargar st., Tehran, Islamic Republic
City
Tehran
Province
Tehran
Postal code
1439951154
Phone
+98 21 8835 1730
Email
infosport@ut.ac.ir
Web page address
http://www.sport.ut.ac.ir
Grant name
Grant code / Reference number
Is the source of funding the same sponsor organization/entity?
Yes
Title of funding source
Vice chancellor for research, Faculty of Tehran University, Physical Education and Sport Sciences
Proportion provided by this source
100
Public or private sector
Public
Domestic or foreign origin
Domestic
Category of foreign source of funding
empty
Country of origin
Type of organization providing the funding
Academic

Person responsible for general inquiries

Contact
Name of organization / entity
University of Tehran Faculty of Physical Education and Sport Sciences
Full name of responsible person
Rasoul Dokht Abdiyan
Position
PHD University student
Latest degree
Master
Other areas of specialty/work
Physiology
Street address
Faculty of Physical Education and Sport Sciences, between 15th and 16th St., North Kargar st., Tehran, Islamic Republic
City
Tehran
Province
Tehran
Postal code
1439951154
Phone
+98 21 6697 5985
Email
rasoulabdiyan11@gmail.com

Person responsible for scientific inquiries

Contact
Name of organization / entity
University of Tehran Faculty of Physical Education and Sport Sciences
Full name of responsible person
Rasoul Dokht Abdiyan
Position
PHD student
Latest degree
Master
Other areas of specialty/work
Physiology
Street address
Faculty of Physical Education and Sport Sciences, between 15th and 16th St., North Kargar st., Tehran, Islamic Republic
City
Tehran
Province
Tehran
Postal code
1439951154
Phone
+98 21 8835 1730
Email
rasoulabdiyan11@gmail.com

Person responsible for updating data

Contact
Name of organization / entity
University of Tehran Faculty of Physical Education and Sport Sciences
Full name of responsible person
Rasoul Dokht Abdiyan
Position
PHD student
Latest degree
Master
Other areas of specialty/work
Physiology
Street address
Faculty of Physical Education and Sport Sciences, between 15th and 16th St., North Kargar st., Tehran, Islamic Republic
City
Tehran
Province
Tehran
Postal code
1439951154
Phone
+98 21 8835 1730
Email
rasoulabdiyan11@gmail.com

Sharing plan

Deidentified Individual Participant Data Set (IPD)
Yes - There is a plan to make this available
Study Protocol
Yes - There is a plan to make this available
Statistical Analysis Plan
Yes - There is a plan to make this available
Informed Consent Form
Yes - There is a plan to make this available
Clinical Study Report
Not applicable
Analytic Code
Not applicable
Data Dictionary
Not applicable
Title and more details about the data/document
Part of the main outcome data
When the data will become available and for how long
Two years after the article was published
To whom data/document is available
Graduate students from all universities in the country
Under which criteria data/document could be used
In order to use the data for doing research in this area
From where data/document is obtainable
rasoulabdiyan11@gmail.com
What processes are involved for a request to access data/document
You will be working with the applicant as soon as possible by sending an email to rasoulabdiyan11@gmail.com
Comments
Loading...