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Study aim
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To investigate the effects of Dexmedetomidine on post-operative pain in patients undergoing Total Abdominal Hysterectomy (TAH).
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Design
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Randomised, controlled, parallel group trial with blinded outcome assessment. Randomisation will be done with simple randomization with random number tables
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Settings and conduct
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Seventy patients in age group 35 to 65 years are randomly divided using random digits table into control and intervention groups (n=35 cases). Researchers responsible for data collection and analyses are blind to the groups allocation.
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Participants/Inclusion and exclusion criteria
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Inclusion criteria are female patients (range age 35-65 years) candidate of Total Abdominal Hysterectomy (TAH), Body mass index (BMI): 18 to 40 kg/m2, and the ASA class I , II; The exclusion criteria are allergic reaction to Dexmedetomidine, history of Dexmedetomidine administration over the past week, history of heart, lung, liver, and kidney diseases, patients with neurological or neuromuscular disorders, patients with anemia or bleeding disorders, consumption of Alcohol, narcotic and Antipsychotic medications, and patients with diabetes.
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Intervention groups
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Anesthesia is performed in all patients with the same drugs, including Midazolam (0.3 mg/kg), Fentanyl (3 mg/kg), Thiopental (5 mg/kg), Atracurium (0.5 mg/kg).
In the Intervention group, immediately after the induction, Dexmedetomidine with a bolus dose of (1 μg/kg) is injected for 15 minutes and then infusion is done with a dose of (0.5 μg/kg) until the end of surgery. In the control group, immediately after the induction, normal saline with a dose of (1 μg/kg) is injected for 15 minutes and then infusion is done with a dose of (0.5 μg/kg) until the end of surgery.
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Main outcome variables
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The postoperative pain, mean arterial pressure and heart rate