Comparison of the effect of Dexmedetomidine and Metoprolol on reducing intraoperative bleeding in patients with craniotomy candidate due to head trauma

Comparison of the effect of Dexmedetomidine and Metoprolol on reducing intraoperative bleeding in patients with craniotomy candidate due to head trauma

This is a double-blind clinical trial conducted on 66 patients with severe head trauma who have undergone craniotomy and who have been referred to the Valiasr Hospital in Arak. Patients are divided in three groups by random numbers.

This is a double-blind clinical trial in Valiasr Hospital in Arak. Patients are divided in three groups by random numbers.We check bleeding and mortality.

Inclusion criteria:Patients with head trauma; patients with ASA class I and II; consciously informed form; candidates of craniotomy due to severe head trauma; maximum operation duration of 150 minute; Patients are operated by a neurosurgeon; 15-75 years Exclusion criteria: hypersensitivity to dexmedetomidine and metoprolol; their operatiion will take more than 150 minutes; patients with severe head trauma candidates of craniotomy that their legal gurdian refuse the informed written consent for participation in the study; Patients with a past medical history of cardio-vascvular diseases, uncontrolled diabetes, seizure and epilepsy, renal failure, liver failure, coagulation disorders, previous cerebrovascular accident or recent myocardial infarction

Intervention group 1:We inject 1 micro gram in kilogram Dexmedetomidine in loading dose‏ ‏ and 0.5 micro gram in kilogram Dexmedetomidine in hours in Infusion. Intervention group 2:We inject 2/5 milligram in kilogram Metoprolol in loading dose‏ ‏ and 0.5 micro gram in kilogram Metoprolol in hours in Infusion. control group: We inject 5 milliliter distilled water as loading dose and 120 milliliter distilled water in Infusion.

bleeding and mortality

Simple individual randomization with random number table in division of groups in two groups A and B . Randomization method: Simple randomization. Random unit: Individual. How to build sequences: First, we set the framework for our statistical society. We started from a table point in a row or column. Given the type of code in the row, we chose the same number of digits. After that, the numbers control the path. We noticed smaller numbers of the statistical community. We have to continue this work so that the number of samples is completed.Even numbers were used for intervention group and odd numbers were used for the control group. Allocation concealment:Numbered drug containers

The participants will not be informed about the drug administered; however, informed written consent will be obtained from the legal gurdian before enrollment in the study. Drugs will be prepared by the anesthisiologist in 5 ml and 20 ml syringes for both groups and labelled A and B. The anonymous syringes will then be given to an anesthesiology resident for administration. Moreover, the intern responsible for the project will also fill out the questionnaires and document data as groups A and B. Therefore, both the anesthesiology resident and intern will be blinded to group assignment and drug administration.