Study of the effects of taurine supplementation on wound healing and metabolic status in patients with diabetic foot ulcer

Determination of the effects of Taurine supplementation on wound healing, serum levels of insulin, triglyceride, total cholesterol, LDL-C, HDL-C, FBS, MDA and hsCRP in patients with diabetic foot ulcer

The present study is a randomized, double-blind, and parallel clinical trial that will be performed on 50 patients with diabetic foot ulcers referred to Razi Hospital of Ahvaz who have criteria for entering the study. Patients are randomly divided into two groups.

The present study is a double-blind clinical trial with the aim of investigating the effect of Taurine on wound healing and metabolic status in patients with diabetic foot ulcers referred to Razi Hospital in Ahvaz. The investigator, physician, patient and data analyst are not aware of the type of treatment.

inclusion criteria: The age range is between 18-60 years, Diabetic foot ulcer grade 3 based on Wagner-Meggitt's benchmark, More than 5 years of illness, patients with type 2 diabetes exclusion criteria: The use of alternative therapies, including hormones or vitamin supplements; Pregnant and nursing women; Patients with Chronic kidney, Liver or pulmonary diseases; ; Chronic or acute inflammatory diseases; Cardiac valve disease; Short bowel syndrome and allergy; Patients with low immune system (autoimmune)

Intervention group: Taurine capsule, 1500 mg daily, 3 times per day, 500 mg capsule each time, for 30 days. Nutricost, USA. Control group: Placebo, starch, 3 times per day, 500 mg capsule each time for, 30 days. Osveh Pharma Co,Iran.

fasting insulin, triglyceride, Total Cholesterol, FBS, HDL-C, LDL-C; Length, width and depth of wound; hs-CRP, NO, GSSG

Assignment of patients to each groups will be done by random block method using block of size 6. Random numbers will be generated randomly by random allocation software. In order to ensure that the selection bias does not occur, the allocation method will be used to allocate a unique code to each patient.

In this double blind study the jars containing the capsules will be the same and neither the patients nor researchers know which capsules are being received. In fact, a third person who knows the contents of the jars distributes them among the participants. The shape and size of the capsules are similar in both groups, while their content is different.