Effect of Separated And Simultaneous Consumption Of Branched-chain Amino Acids And Glutamine On Muscle Damage Indices After Eccentric Resistance Exercise
The purpose of this study was to compare the effect of BCAA and glutamine supplements and their synergistic effect on serum muscle injury indices and pain after a session of eccentric resistance exercise.
Design
A clinical trial with a control group, with parallel groups, randomized
Settings and conduct
Performing resistance training causes muscular injuries. This study is conducted on 40 non-athlete male students of the University of Gilan. The subjects are divided into four groups and the effects of supplemens and placebo on the indicators of muscle damage are measured.
Participants/Inclusion and exclusion criteria
ٍEntery conditions:Non-smokers and untrained males
Exit condition: supplement consumption
Intervention groups
Group 1: Branched amino acids (0.1 g / Kg), 30 minutes before exercise
Group 2: Glutamine (0.1 g / Kg), 30 minutes before exercise
Group 3: Branched amino acids (0.1 g / Kg) and glutamine (0.1 g / Kg), 30 minutes before exercise
Group 4: Placebo (maltodextrin) (0.1 g / kg), 30 minutes before exercise
Effect of Separated And Simultaneous Consumption Of Branched-chain Amino Acids And Glutamine On Muscle Damage Indices After Eccentric Resistance Exercise
Public title
Effect Of Branched-chain Amino Acids And Glutamine On Muscle Damage
Purpose
Prevention
Inclusion/Exclusion criteria
Inclusion criteria:
Male
Non-smoker
Untrained
Exclusion criteria:
Illness
Supplements consumption
Age
No age limit
Gender
Male
Phase
N/A
Groups that have been masked
Outcome assessor
Data analyser
Sample size
Target sample size:
40
Randomization (investigator's opinion)
Randomized
Randomization description
The subjects will be divided into four groups A and B, C and D using simple randomization method and by random number table. Therefore, the unit of randomization will be individuals. First, a list of all participants will be provided. Then, by deleting the names from the list, individuals will be assigned to the study groups on the basis of the numbers already assigned to each person. Since the numbers of the participants (not their names) are assigned to the groups, and this will be done once, the researcher will not have the opportunity to change the status of the assignment of individuals or predict it. The study groups include (A) branched amino acids, group (B) glutamine, group (C) branched amino acids and glutamine and group (D), placebo.
Blinding (investigator's opinion)
Single blinded
Blinding description
The data analyst, and outcome assessor in the study do not know who is in the intervention groups and who is in the placebo group.
Placebo
Used
Assignment
Parallel
Other design features
Secondary Ids
empty
Ethics committees
1
Ethics committee
Name of ethics committee
Research Ethics Committeeof Sport Sciences Research Institute
Street address
No.3, 5 th St., Mir Emad St. Motahari Ave.
City
Tehran
Province
Tehran
Postal code
1587958711
Approval date
2019-04-28, 1398/02/08
Ethics committee reference number
IR.SSRI.REC.1397.465
Health conditions studied
1
Description of health condition studied
muscle damage
ICD-10 code
ICD-10 code description
Primary outcomes
1
Description
Serum keratin kinase enzyme activity
Timepoint
Before, 24 hours, 48 hours and 72 hours after intervention
Method of measurement
Level of enzyme activity by photometric method
2
Description
Serum lactate dehydrogenase enzyme activity
Timepoint
Before, 24 hours, 48 hours and 72 hours after intervention