Premature rupture of membranes (PROM) occurs in 8% of women at term. Prostaglandins such as misoprostol and oxytocin are used for induction of labor in PROM. In this study, 99 term pregnant women with PROM entered the study. Inclusion criteria: term pregnancy, demonstrated PROM <4 hours, single fetus pregnancy, parity1 and 2, cephalic presentation, labor pain were not started, normal cardiophitogram in fetus. Exclusion criteria: Previous uterine surgery, multiple pregnancy, abnormal presentations, fetal distress, weight of fetus>4kg, pregnancy>41 weeks, cord prolapse, labor pain, vaginal bleeding, diabetes, Asthma, chronic hypertension, preeclampsia, chorioamnionitis. Patients were randomized in two groups and they were matched using maternal age, parity and gestational age. First group was given 50 µgr of oral misoprostol every 4 hours for two doses and second groups was given two doses of placebo. Induction with oxytocin started after 12 hours of PROM if the delivery or effective contraction did not start. Solution of oxytocin was 10 IU in 1 lit serum (Ringer) that was started with 4mIU per/ min and added every 20 min up to 36 mIU per/min. The onset of labour pain and delivery, the mode of delivery, and maternal and fetal complications were the main outcome.