Silicone Gel Versus Contractubex Gel effect on upper-extremity postsurgical Scars

Determination of Silicone Gel Versus Contractubex Gel effect on upper-extremity post surgical Scars

Randomized, Double-blind, parallel, clinical trial, designed during one years on 120 upper extremity sharp injury patients from January 2018 to January 2019 in 15 Khordad Hospital (Tehran, Iran), affiliated to Shahid Beheshti University of Medical Sciences.

In this double-blind trial study that conduct on Sharp injury, to the upper extremity patients who referred to the 15 khordad Hospital of Shahid Beheshti University of Medical Sciences, the participant, investigator and outcomes assessor were not familiar with the groups. From the day of suture removal (ten day), the treatment was applied one time daily in group one and two time daily in group 2, half a fingertip for every 10 cm of wound length (equivalent to one gram of contractubex gel or silicone gel), for 4 months. Group 3 left untreated as control. Patients were followed up for 4 months and outcomes were compared in the three groups between the second week and the sixteenth week.

Sharp injury to the upper extremity patients who referred to the 15 khordad Hospital of Shahid Beheshti University of Medical Sciences

Intervention 1 (Silicone gel) : Kelo-cort™; Advanced Bio-Technologies, Silverdale, WA, USA) (group 1; 40 patients) Intervention 2(Onion extract): Contractubex™, Merz Pharma, Frankfurt, Germany) gel (group 2; 40 patients) Control: Not treated

post surgical scar formation assessment using Vancouver scale score

Simple randomization using drawing sealed envelopes and a computer-based table of randomization

In this double-blind trial study, the participant, investigator and outcomes assessor were not familiar with the groups. we used identify code for each patient and also used unlabeled medication with same box shape for each group. The safety and data monitoring committee was informed about the study groups.