Clinical outcomes of colonic J-pouch, straight colorectal and side-to-end anastomosis procedures in rectal cancer

The aim of this study is to compare the performance and clinical outcome of three methods of colorectal anastomosis, Straight, Side to end, and J-Pouch methods in patients with colorectal cancer.

This randomized, single-blind, parallel, clinical trial was performed during two years from March 2017 to September 2018 in Imam Khomeini Hospital (Sari, Iran) on 60 colorectal cancer patients. Sixty patients were randomly divided into three groups by randomly drawing sealed envelopes, using a computer-based table of randomization by a surgical assistant.

The demographic and clinical data were extracted from medical records and patients were followed up to evaluate functional characteristics of anastomotic methods.The participants, observer and data analyzer were not familiar with three types of anastomosis surgery in this study.However, the main researcher (surgeon) was informed about the groups.

The inclusion criteria were as follows: all patients with 1) rectal adenocarcinoma, located 4 to 12 cm from anal verge who referring to Imam Khomeini Hospital in Sari from March 2017 to September 2018, 2) Complete medical documents 3) Possible oncological and functional sphincter preserving.The exclusion criteria were as follows: 1) Patients with incomplete documents, 2) continued treatment in other centers, 3) unavailable information 4) unknown tumor stage.

Group A was undergone anterior resection with straight colorectal anastomosis (SA).group B was undergone colonic J-pouch (CJP) anastomosis. group C was undergone side-to-end colorectal anastomosis.

Demographic data (age, sex), Tumor characteristics were extracted from patients' documents and recorded in a questionnaire. Clinical performance evaluation was performed on the seventh day, the second month, and the sixth month.

Simple randomization of individual by randomly drawing sealed envelopes, using a computer-based table of randomization by a surgical assistant

In this single-blind study, the participants were not familiar with three types of anastomosis surgery in this study. In addition, the observer, who completed the questionnaire, was not familiar with the groups. Similarly, the data analyzer did not know the study groups. However, the main researcher (surgeon) was informed about the groups, and all surgical procedures were performed by the same surgeon. The safety and data monitoring committee was also informed about the study groups.

There is not a plan to make this available