Comparison of the effect of Tamsulosin and Placebo on prevention of urinary retention after Herniorrhaphy, Varicocelectomy, and Anorectal Surgery.

Determination of the effect of Tamsulosin and Placebo on prevention of urinary retention after Herniorrhaphy, Varicocelectomy, and Anorectal Surgery.

Clinical trials with a control group, with parallel groups, double-blind, randomized.

This study will be conducted to evaluate the effect of Tamsulosin and Placebo on prevention of urinary retention after Herniorrhaphy, Varicocelectomy, and Anorectal Surgery in Vasei Hospital of Sabzevar. Patients will be randomly assigned to the intervention (0.4 mg Tamsulosin capsule) and control (placebo) group. The response to treatment is evaluated using 24-hour urine volume measurements for study groups.

Inclusion criteria: Patients under the age of 50 years, Patients undergoing urology or general surgery. Exclusion criteria: Patients with the the symptoms of urinary tract infection before surgery, Patients with a history of urinary retention, Patients with a history of neurological disease, Patients with a history of pelvic surgery, Patients with a history of using Benzodiazepine, beta-agonists, and alpha-agonist prior to surgery

Intervention group: Patients in this group receive 3 doses of Tamsulosin capsule 0.4 mg (2 doses prior to surgery 12 hours apart and one dose 6 hours after surgery) orally. Control group: Patients in this group receive 3 doses of placebo capsules (2 doses prior to surgery, 12 hours apart and one dose 6 hours after surgery) orally.

Determine urinary retention

Randomization was conducted based on a permutation block by a statistical consultant using random allocation software and the output sequences A and B are available to the researcher, Accordingly, 6 blocks were allocated to patients, in each block, 2 from A treatment group, 2 from the B treatment group were placed. Eventually, after completing the blocks group A was treated with Group A is treated with Tamsulosin 0.4 mg and Group B is being treated with placebo. First, we determine all sixsome modes in which two individuals are assigned to group A and two to group B. Then we assign one of the digits 1 to 6 to each of the sixsome combinations (which includes thirty-six modes). In the next step, we must randomly select 6 blocks of six and write their combinations in succession. For this we have to make 6 samplings with replacement from a six-member community; 6 times, choose a random number between 1 and 6 and this process will continue until the end of the sampling and the difference between the two groups will not exceed a maximum of two (half the size of the block).

Each person in the study will be assigned code A and B, that the researcher will only be known of the type of groups. Clinical care and participants are unaware of the groups. It should be noted that Tamsulosin and placebo are similar in appearance, color, and packaging.

No more information