The purpose of this study was to investigate the effects of apple cider and white vinegars on glycemic response and appetite in healthy subjects. A total of 30 healthy volunteers with normal body mass indices (19-25 kg/m2) and without drug therapy participated in this cross-over study after obtaining informed consent. The subjects came to the laboratory in the morning after an overnight fast. A fasting blood sample was taken by EasyGluco glucose monitoring system (finger-stick) and the subject’s feeling of hunger/satiety was rated using a subjective rating scale (VAS) before the meal serving. The test meal consisting 200 grams potatoes (weighed without skin) containing 50 grams available carbohydrate cooked on the morning of the test day. Subjects were randomly divided into two groups taking the test meal with either 30 ml of white or apple cider vinegars. Test meal will be consumed in 10-14 minutes and blood samples were obtained at 30, 90, 120 minutes after starting to eat. The feeling of hunger/satiety was also rated at, 30, 90, and 120 min after the meal. The tests were repeated with different kind of interventions two weeks after the first trial.
General information
Acronym
IRCT registration information
IRCT registration number:IRCT138706141197N1
Registration date:2010-04-24, 1389/02/04
Registration timing:retrospective
Last update:
Update count:0
Registration date
2010-04-24, 1389/02/04
Registrant information
Name
Reza Mahdavi
Name of organization / entity
Faculty of Health & Nutrition, Tabriz UniV. of Medical Sciences
Country
Iran (Islamic Republic of)
Phone
+98 41 1335 7584
Email address
mahdavir@tbzmed.ac.ir
Recruitment status
Recruitment complete
Funding source
Nutritional Research center
Expected recruitment start date
2009-10-23, 1388/08/01
Expected recruitment end date
2010-03-20, 1388/12/29
Actual recruitment start date
empty
Actual recruitment end date
empty
Trial completion date
empty
Scientific title
The effects of Apple Cider and White Vinegars on Glycemic Response and Appetite in healthy subjects
Public title
The effects of Apple Cider and White Vinegars on Glycemic Response and Appetite in healthy subjects
Purpose
Prevention
Inclusion/Exclusion criteria
Inclusion criteria: signing informed consent, healthy volunteer, age 20-40 years, normal BMI indices,
Exclusion criteria: receiving insulin or antihyperglycemic drugs or appetizers, smoking, and presence of gastrointestinal disorders
Age
From 20 years old to 40 years old
Gender
Both
Phase
N/A
Groups that have been masked
No information
Sample size
Target sample size:
30
Randomization (investigator's opinion)
N/A
Randomization description
Blinding (investigator's opinion)
Not blinded
Blinding description
Placebo
Not used
Assignment
Crossover
Other design features
Secondary Ids
empty
Ethics committees
1
Ethics committee
Name of ethics committee
The Research Ethics Committee of Tabriz University of Medical Sciences
Street address
Tabriz University of Medical Sciences
City
Tabriz
Postal code
Approval date
2010-02-23, 1388/12/04
Ethics committee reference number
8816
Health conditions studied
1
Description of health condition studied
healthy subjects
ICD-10 code
ICD-10 code description
Primary outcomes
1
Description
Accuracy and precision of the Easy-Gluco and Accuchek (self blood glucose monitoring machines) with laboratory methods
Timepoint
beginning of the trial
Method of measurement
Blood sampling with glucose monitoring system (finger-stick) and laboratory methods
2
Description
Glycemic response
Timepoint
At the baseline and 30, 90, and 120 minutes after taking white and apple cider vinegars
Method of measurement
Blood sampling with glucose monitoring system(finger-stick)
3
Description
Appetite
Timepoint
At the baseline and 30, 90, and 120 minutes after taking white and apple cider vinegars
Method of measurement
VAS Questionnaire
4
Description
Daily Fat
Timepoint
The day before, the trial day and the day after taking white and apple cider vinegars
Method of measurement
24 hour dietary recall
5
Description
Total Daily Calorie
Timepoint
The day before, the trial day and the day after taking white and apple cider vinegars
Method of measurement
24 hour dietary recall
6
Description
daily taken charbohydrates
Timepoint
The day before, the trial day, and the day after taking white and apple cider vinegars
Method of measurement
24 hour dietary recall
7
Description
Daily protein
Timepoint
The day before, the trial day and the day after taking white and apple cider vinegars
Method of measurement
24 hour dietary recall
Secondary outcomes
1
Description
Insulin response and appetite control
Timepoint
Monitoring during the trial
Method of measurement
Blood sampling with glucose monitoring system(finger-stick) and VAS Questionnaire
Intervention groups
1
Description
30 mL of white vinegar supplementation
Category
Prevention
2
Description
30 mL of Apple cider vinegar supplementation
Category
Prevention
Recruitment centers
1
Recruitment center
Name of recruitment center
Health and Nutrition Faculty ,Tabriz University of Medical Sciences
Full name of responsible person
Dr. Reza Mahdavi
Street address
Tabriz University of Medical Sciences
City
Tabriz
Sponsors / Funding sources
1
Sponsor
Name of organization / entity
Nutritional Research center
Full name of responsible person
Dr. Alireza Ostad Rahemi
Street address
Health and Nutrition Faculty,Tabriz University of Medical Sciences
City
Tabriz
Grant name
Grant code / Reference number
Is the source of funding the same sponsor organization/entity?
Yes
Title of funding source
Nutritional Research center
Proportion provided by this source
100
Public or private sector
empty
Domestic or foreign origin
empty
Category of foreign source of funding
empty
Country of origin
Type of organization providing the funding
empty
Person responsible for general inquiries
Contact
Name of organization / entity
Nutritional Research center of Tabriz university of medical science
Full name of responsible person
Dr.Reza Mahdavi
Position
Ph.D of Nutrition
Other areas of specialty/work
Street address
Tabriz University of Medical Sciences
City
Tabriz
Postal code
Phone
+98 41 1335 7580
Fax
Email
mahdavir@tbzmed.ac.ir
Web page address
Person responsible for scientific inquiries
Contact
Name of organization / entity
Tabriz university of medical science
Full name of responsible person
Raheleh Rasouli
Position
MS student of Nutrition
Other areas of specialty/work
Street address
Tabriz University of Medical Sciences
City
Tabriz
Postal code
Phone
+98 41 1335 7580
Fax
Email
Raheleh715@yahoo.com
Web page address
Person responsible for updating data
Contact
Name of organization / entity
Tabriz University of Medical Sciences
Full name of responsible person
Raheleh Rasouli
Position
MS student
Other areas of specialty/work
Street address
City
Tabriz
Postal code
Phone
Fax
Email
Raheleh715@yahoo.com
Web page address
Sharing plan
Deidentified Individual Participant Data Set (IPD)