Comparison of the effect of vaginal misoprostol alone and vaginal misoprostol simultaneously with laminaria in induction of second trimester pregnancy (14-20 weeks) in patients referred to Imam Ali Hospital's Hospital (Clinical Practice)

This study is performed to determine the effect of vaginal misoprostol with laminaria in comparison with vaginal misoprostol alone in termination of pregnancy of the second trimester of pregnancy (14 to 20 weeks).

Clinical trial with parallel control groups, one blind, randomized, On 90 patients referring to the maternity of Ali ibn Abi Talib hospital, which are14 to 20 weeks pregnant and are a candidate for termination of pregnancy.

In the intervention group, the Laminaria will be inserted into the cervix. Then, at the same time, the misoprostol suppository contains 400 micrograms in the posterior Fornix of the vagina and examines the patient every 8 hours, and if we do not pass the fetus after 8 hours, we will repeat the vaginal misoprostol. . This process continues for up to 6 doses and, if not eliminated, until then, surgery is used to terminate the pregnancy. In the control group, misoprostol suppository 400 micrograms will be prescribed, According to the intervention group.   .

Entry requirements: Pregnant women between the weeks 14-20 weeks of pregnancy admitted to Imam Ali Hospital who are candidates for termination of pregnancy due to severe anomalies or fetal death. Single-swelling conditions, parietal 1 to 3, painless and uterine infections Non-arrival conditions: Allergy to medications, taking anticoagulants and corticosteroids, having some special diseases, history of previous anesthetic on the uterus, parity of more than three, Peruvian pairs, and more.

In the first group, Laminaria is inserted into the cervix. Together with 400 micrograms of vaginal progesterone every 8 hours to 6 times and another 400 micrograms of vaginal progesterone every 8 hours to 6 times.

The average need for curettage, Labor time, Hospital admission time after termination of pregnancy.

Accidental assignment to intervention and control groups. To minimize the potential confounding effects, all participants with all the conditions for entry into the study will be randomized. Randomized blocked sampling will be based on gradual referral of eligible samples.

Since the therapist is aware of the type of treatment and Laminaria and Misoprostol should be examined by the therapist for several hours, it is a blind side effect and patients are unaware of the treatment. We also use an assessment that does not know the treatment of the groups and we ask the evaluator for the statistics to get the statistics.