The aim of this study is to determine the effect of intravenous prednisolone on blood pressure, pulse rate, and pain severity in patients undergoing septoplasty surgery.This study is a clinical trial, single center, with random allocation. The patients will allocated randomly in the study groups according to encoded sheets. The population of the study are the eligible patients hospitalized in Kashani Hospital in Shahrekord. Inclusion criteria are the patients aged 20 to 50 years who are candidate for septoplasty surgery. The patients with any steroids contraindication, addicted to opoioids, chronic diseases such as hypertension, and under treatment with anxiolytic medications will excluded. Seventy-two patients will randomly allocated in prednisolone or control (routine treatment) groups (36 in each group). In prednisolone group, 1 mg/kg prednisolone was infused before surgery, but in control group, in addition to routine anesthesia, distilled water with the same volume will infused as placebo. All patients in both groups will received 10 mg diazepam (orally) as premedication in the night before surgery. On the other hand, induction of anesthesia will done using 5 mg/kg Sodium thiopental, 0.5 mg/kg Atracurium besilate, and 4 microgram/kg Fentanyl (intravenous) for patients in two study groups. In addition, twenty minutes after beginning the surgery 2 microgram/kg intravenous Fentanyl will used.
The patients’ blood pressure and heart rate will evaluated one hour before operation, ten minutes after beginning of surgery, and five minutes after entrance to recovery. In addition, after full recovery the pain severity will measured by Visual Analogue Scale.