Comparative study of the effect of hydroalcoholic extract of chamomile and flaxseed oil on pelvic pain, dyspnea and dysmenorrhea in patients with endometriosis

1- Determination of severity of chronic pelvic and dysmenorrhea dysparonychia in chamomile group before and after chamomile capsule administration. 2- Determination of severity of dysmenorrhea, chronic pelvic pain and dysparonychia in flaxseed group before and after flaxseed oil capsule administration. 3- Determination of severity of chronic pelvic pain and dysmenorrhea and dysparonychia in control group before and after placebo capsule administration.

Clinical trial with control group, parallel groups, double blind, randomized, 120 sample size in the sampling phase

Clinical trial study is performed at Jihad Infertility Center and Reyhaneh Infertility Center affiliated to Qom University of Medical Sciences.

Exclusion criteria: Any known physical disorders (pelvic inflammatory disease, autoimmune or metabolic disease) and known psychological problems Alcohol and tobacco use Use of supplements Exclusion criteria: Incorrect daily intake and consumption (if used within one hour after using chamomile capsule, flaxseed oil and placebo) Chamomile capsule and flaxseed capsule by patients Unwillingness to continue studying

Chamomile group: The group that consumes 9 g of chamomile daily (3 g every 8 hours) Flax Seed Group:The group receiving 6 g of flaxseed oil extract (2 g every 8 hours) The placebo group: The group that found 500 mg of avicel in each capsule

Severity of dysmenorrhea, chronic pelvic pain, dysparonychia

In this study, the limited randomization method of block randomization will be used. Blocking is usually used to balance the number of samples assigned to each of the study groups. This feature helps researchers to ensure that the number of samples assigned to each of the study groups is equal in cases where intermediate analyzes are required during the sampling process. The size of all the blocks is equal and in this We will have a three-group trial of 36 blocks of 3. Randomization tool also uses random sequence generation software that these random sequence generation software in addition to simple randomization are able to generate random sequence by blocking method. For concealment, random allocation concealment is used, which is the method used to execute a random sequence on study participants, so that the assigned group is not known before the individual is assigned. Using opaque envelopes sealed with a random sequence in which each of the random sequences created on a card It is registered and the cards are placed in the letter envelopes in order To be. In order to maintain a random sequence, the envelopes are numbered in the same way on the outer surface. Finally, the lids of the letter envelopes are glued and placed inside a box, respectively. At the beginning of the sampling, one of the envelopes of the letter is opened and the assigned group of the participant is revealed, based on the order of entry of the eligible participants

Starting the treatment cycle, if the patient chooses code A, medication A is given and either B or C is given (for example A recipient of chamomile capsule and B code for flaxseed oil and C code for placebo). The coding is performed by a pharmacist.) The drugs are quite similar in appearance and are unknown to the researcher and patient, and are only known to the pharmacist but are quite similar in appearance. Each medication is packaged in separate packages coded with the letters A, B, and C and provided to research units.

Individual data related to participants

Start the access period 6 months after printing the results

It will only be available to researchers working in academic and scientific institutions

Items that are in line with the studied variables

first name and last name: Fatemeh Mahnazadeh Fallahieh Email: mohana6492@gmail.com

After requesting the email, the data will be sent within a week of the applicant's email