For the purpose of the endometrial preparing, there are different regimes including using different products of estrogen and progesterone.
Estrogen is available as a composite of valerate estradiol tablet, dermal jell, dermal and vaginal patch.
Taking the side effects of oral esteroid on lipoprotein and the coagulation factors, it is useful to use estrogen jell. As a result, taking the side effects of oral esteroid into account, it is important to use products with less side effects such as jell.
A study was conducted in 2016-2017 on 100 infertile women who were under treatment with the acceptance conditions (between 20-45 years old, and are candidate to frozen embryo transfer). The participants took part in the study for 6 months in Vali-asr Clinic for Infertility, and without agonist suppression they were randomly in single blind divided into two groups.
In the two groups, the first day of menstrual cycle the amount of estradiol was checked. In the first group from the first day of menstrual cycle 6 mg of estradiol was daily given. After one week, ultra-sound was done, and by the start of the triple-line endometrium estradiol was checked.
In the second group, from the first day of menstrual cycle 4.5 mg of estradiol jell equaling three line of the ruler and 4 mg of oral estradiol in the upper arm or thigh area was used.
The two groups were compared according to estradiol serum amount, size of endometrium thickness (primary outcome) and clinical pregnancy rate (secondary outcome).