Comparison Between Sublingual Buprenorphine and Fentanyl Intravenous Pump for Postoprative Pain Relief After Open Cholecystectomy Surgery.

Comparison Between Sublingual Buprenorphine and Fentanyl Intravnous Pump for Postoperative pain relief after open Cholecystectomy Surgery

The present study was a double blind clinical trial, in this study, 80 patients undergoing open Cholecystectomy were randomly divided into two groups and get into the study. the intervention group of Patients receiving Sublingual Buprenorphine Tablet and Placebo Pump and the control group received Placebo and intravenous Fentanyl Pump.

Trial will include patients undergoing open Cholecystectomy in Fatemi and Imam Khomeini hospitals in Ardabil city.The study is randomized simple randomized, The drugs were in separate packages and two envelopes and Patients and injectors have no knowledge of the contents of the envelope. In the intervention group, Sublingual Buprenorphine tablet administered 0.4 mg in 6, 12 and 18 hours recovey and placebo pump 50 cc normal saline in recovery and continued for 24 hours, if pain is not controlled, PCA is injected every 15 minutes.In the control group, Placebo Tablets were administered at 6,12 and 18 h,50 cc intravenous Fentanyl Pump (40 cc Fentanyl and 10 cc normal saline) embedded and half a cc (20 micrograms) of stat is injected and if the pain is not controlled, PCA is given by the Patient.then the VRS Score, Nausea, Vomiting, sedation of both groups were evaluated during the study times.

Inclusion criteria:ASA I و II,No other surgery, Age range 20 to 50 years. Exclusion criteria:History of opium and nerve medication use , ASA ≥ 3, Other surgery concurrent and complicated.

Administration of Sublingual Buprenorphine and Placebo Pump to the intervention group,Administration of Placebo and Fentanyl Pump to control group.

Reduction of pain after open Cholecystectomy

After patients were allowed to enter the study 80 patients were selected using simple sampling and the selected patients will be divided into two groups by random block design with 4 blocks. In this case all possible modes were considered to accommodate the letters AABB which is 6 modes. These 6cases were embedded in 6 papers and the papers were embedded in a black bag. Then we will make 20 paper bags every time. We draw a piece of paper write down the letters in it and we will add the next letter in the next drawing followed by the previous note we will have 80 letters in the end and at the time of sampling each person will receive a special letter in order of entry into the sample and so the people feel into one group .

The first group of 40 patients receiving Sublingual Buprenorphine Tablet and intravenous placebo Pump The second group will consist of 40 patients receiving Sublingual placebo Tablet and intravenous Fentanyl Pump. All Patients will be anesthetized by one-way treatment Protocol. Given that the study is randomly blocked,Buprenorphine and Placebo Buprenorphine and Fntanyl Pump and placebo pump separately and in two packs (Containing one pump and one Tablet) with specific codes B and A (Pack A containing Sublingual Buprenorphine and Placebo Pumps and and Pack B containing Placebo Tablets and Fentanyl Pumps) and The drug injector (Anesthetic Technician) has no information about the contents of the pack Select Pack A or B based on the Patient group. already specified are provided and every morning before the operation the number of Surgeries will be eliminated the same day.Start prescribing housing content envelopes after complete Cholecystectomy And it will be done in recovery. Patients will not be informed about the type of drug they receive.

Due to Ethical Problems and Patient safety, The publish of IPD not applicable.