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Study aim
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Evaluation of Safety and efficacy of hydrogen peroxide 35% topical solution, in Comparision to cryotherapy in on treatment of patients with senile lentigo referring to Shohada-e-Tajrish and Loghman-e-Hakim hospital in 1397-98.
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Design
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A clinical trial without a control group, with parallel, not blinded, randomized groups
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Settings and conduct
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After obtaining the necessary authorization for the project, 33 patients with senile lentigo referred to Loghman Hakim and Martyrs Tajrish hospitals during the years 1976-97 are included in the study.
After explaining the procedure and obtaining written informed consent from patients, we apply 35% hydrogen proxide topically on a lentigo pad with a cotton swab and allow the drug to remain in the area for 15 to 20 minutes. It is washed off 6 hours after taking the drug-soaked area.
In the cryotherapy recipient group, the liquid nitrogen is applied to the lentigo surface by a cotton swab and allowed to remain in the area for 3 to 5 seconds.
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Participants/Inclusion and exclusion criteria
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Inclusion criteria :
They are over 16 years old, Do not meet the exclusion criteria, Have an informed consent to participate in the study
Exclusion criteria:
Person with Fitzpatrick skin type V, People with drug allergies, Under 16 years, I am pregnant or nursing, People who have used other treatments in the last 4 weeks to eliminate lentigo (such as cryotherapy or imaging modality ointment), Vitiligo patients
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Intervention groups
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In each patient, hydrogen proxide and cryotherapy are used to treat lesions on one side of the body randomly.
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Main outcome variables
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Age;
Sex;
Fitzpatrick skin type ;
Duration of illness;
Number of lesions;
lesion site;
Previous treatment history;
Recurrence history following previous treatment;
Recurrence rate;
Dosage;
Effectiveness of the drug;
Severity of drug side effects;
Recurrence after treatment;