The effect of citrulline supplementation on serum lipids, liver enzymes, inflammatory markers and hepatic steatosis in patient with nonalcoholic fatty liver disease

The main purpose: the effect of citrulline supplementation on serum lipids, liver enzymes, inflammatory markers and hepatic steatosis in patients with nonalcoholic fatty liver randomized, double-blind, placebo-controlled inclusion criteria: age 18 years and above;Concentrations of liver enzymes ALT and AST greater than 1.5 times normal;Evidence of nonalcoholic steatohepatitis in Fibroscan Exclusion criteria:Not continue to cooperation;Those less than 10% supplemen at the end of the sixth and twelfth week consume. Summary of the project:In this study, patients with non-alcoholic fatty liver if they wish to participate in the study consent form them to be taken.After 12 to 14 hours of fasting, 5 cc of blood is taken to measure their blood serum concentrations of lipids, inflammatory factors and other serum biochemical parameters and kept in the freezer.Participants randomly using the divided randomly classified into two groups:supplement and placebo group.Patients group supplement recived daily 2 grams of citrulline for three months and Patients in the control group recived placebo daily 2 grams. At the end of the third months, anthropometric, dietary recall and serum is taken and with fibroscan, changes in the degree of hepatic steatosis recorded

National Nutrition and Food Technology Research Institute Iran Iran University of Medical Sciences of Colorectal Research Center